Leslie A. Geddes

Bio: Leslie A. Geddes is an academic researcher from Purdue University. The author has contributed to research in topics: Cardiac output & Defibrillation. The author has an hindex of 54, co-authored 257 publications receiving 11394 citations.

Tissue graft composition

Abstract: This invention relates to a method for preparation of a tissue graft composition from a segment of small intestine. A tissue graft composition is described which comprises the tunica submucosa of a segment of small intestine of a warm-blooded vertebrate wherein the tunica submucosa is deliminated from the tunica muscularis and at least the luminal portion of the tunica mucosa. The tissue graft composition has been shown to have excellent mechanical characteristics, as well as non-allergenicity and non-thrombogenicity in applications as vascular autografts, vascular allografts, and vascular heterografts.

Method and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillation

Abstract: A closed-loop variable frequency vagal stimulation apparatus for control of ventricular rate during atrial fibrillation. In one embodiment the apparatus includes a stimulator applied to the left vagus nerve and a proportional controller programmed to automatically and continuously adjust the vagal stimulation frequency proportionally as a function of the difference between actual and desired ventricular excitation rates. In a second embodiment the apparatus includes a vagal nerve stimulator and a controller which automatically adjusts the vagal stimulation frequency as a function of the difference between ventricular excitation rate and arterial pulse rate in order to eliminate or minimize pulse deficit.

Method and apparatus for thermally destroying a layer of an organ

Abstract: Method and apparatus are disclosed for thermally destroying a layer of an organ such as the mucosal layer of the gallbladder. The apparatus includes a catheter having an elongated member having a plurality of lumens therein. At the distal end of the elongated member is an electrode for emitting radiofrequency current to the mucosal layer. Also at the distal end is a capacitive balloon electrode surrounding the current-emitting electrode for containing an electrolyte solution and for distributing the radiofrequency current to the mucosal layer. The balloon electrode is expanded with the electrolyte solution to conform and make contact with the mucosal layer. The electrolyte solution has a resistivity significantly less than the resistivity of the gallbladder wall, as well as the gallbladder bile, to cause a concentrated power deposition in the mucosal layer. The distal end of the catheter is endoscopically inserted into the body of the gallbladder by a retrograde route through the duodenum, common bile duct and cystic duct. While the balloon electrode is being expanded, the bile present in the gallbladder is drained through one of the lumens in the elongated member. The apparatus also includes a radiofrequency generator for supplying radiofrequency current to the current-emitting electrode. The current-emitting electrode is energized for a period of time to cause the mucosal layer to be heated for a predetermined period of time to thermally coagulate the mucosal layer of the gallbladder and cystic duct. A dispersive electrode is positioned on the skin of the patient's body to facilitate a complete circuit back to the generator without causing trauma to the patient.

Characterization of the Oscillometric Method for Measuring Indirect Blood Pressure

Abstract: In this study, human subjects and dogs were used to determine the ability of the oscillometric method to indicate systolic and diastolic pressure. In the human studies, the auscultatory method was used as the reference. In the animal studies, directly recorded blood pressure was used as the reference. The ability of the sudden increase in cuff pressure oscillations during cuff deflation to indicate systolic pressure was examined and found to overestimate systolic pressure slightly in man, but more in animals. Systolic pressure was encountered when the cuff pressure oscillations were about one half of their maximum amplitude. However, in both man and animals the ratio was not constant; although the range was less in man than in animals. Diastolic pressure was encountered when cuff-pressure oscillation amplitude was about 0.8 of the maximal amplutide. This ratio for diastolic pressure was not constant over a range of diastolic pressure. The range of variability was less for man than for the dog.

An electrosurgical instrument

Abstract: An electrosurgical instrument is disclosed for the treatment of tissue in the presence of an electrically-conductive fluid. The instrument comprises an instrument shaft (32), and a tissue treatment electrode (31) at one end of the shaft, the tissue treatment electrode being constructed to define a plurality of pockets for trapping electrically-conductive fluid. Alternatively, the tissue treatment electrode (81) is made from an electrically-conductive material (81a) and is coated with a resistive inert material (81b) which is effective to increase the local power density within the tissue treatment electrode.

ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation): Developed in Collaboration With the European Heart Rhythm Association and the Heart Rhythm Society

Abstract: Sidney C. Smith, Jr, MD, FACC, FAHA, FESC, Chair; Alice K. Jacobs, MD, FACC, FAHA, Vice-Chair; Cynthia D. Adams, MSN, APRN-BC, FAHA; Jeffery L. Anderson, MD, FACC, FAHA; Elliott M. Antman, MD, FACC, FAHA[‡][1]; Jonathan L. Halperin, MD, FACC, FAHA; Sharon Ann Hunt, MD, FACC, FAHA; Rick Nishimura,

Part 8: Adult Advanced Cardiovascular Life Support 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care

Abstract: The goal of therapy for bradycardia or tachycardia is to rapidly identify and treat patients who are hemodynamically unstable or symptomatic due to the arrhythmia. Drugs or, when appropriate, pacing may be used to control unstable or symptomatic bradycardia. Cardioversion or drugs or both may be used to control unstable or symptomatic tachycardia. ACLS providers should closely monitor stable patients pending expert consultation and should be prepared to aggressively treat those with evidence of decompensation.

Analyte Monitoring Device And Methods Of Use

Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.