L
Leslie A. Pratt
Researcher at Harvard University
Publications - 9
Citations - 3748
Leslie A. Pratt is an academic researcher from Harvard University. The author has contributed to research in topics: Biofilm & Flagellum. The author has an hindex of 8, co-authored 9 publications receiving 3501 citations.
Papers
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Journal ArticleDOI
Genetic analysis of Escherichia coli biofilm formation: roles of flagella, motility, chemotaxis and type I pili
Leslie A. Pratt,Roberto Kolter +1 more
TL;DR: It is demonstrated that E. coli forms biofilms on multiple abiotic surfaces in a nutrient‐dependent fashion and type I pili (harbouring the mannose‐specific adhesin, FimH) are required for initial surface attachment and thatMannose inhibits normal attachment.
Book ChapterDOI
Genetic approaches to study of biofilms
George A. O'Toole,Leslie A. Pratt,Paula I. Watnick,Dianne K. Newman,Valerie B. Weaver,Roberto Kolter +5 more
TL;DR: This article operationally defines a biofilm as bacteria that are attached to a surface in sufficient numbers to be detected macroscopically.
Journal ArticleDOI
Exopolysaccharide Production Is Required for Development of Escherichia coli K-12 Biofilm Architecture
TL;DR: Surprisingly, it is found that colanic acid production is not required for surface attachment, which is critical for the formation of the complex three-dimensional structure and depth of E. coli biofilms.
Journal ArticleDOI
The outer membrane protein, antigen 43, mediates cell-to-cell interactions within Escherichia coli biofilms.
TL;DR: It is reported that Ag43 contributes to E. coli biofilm formation in glucose‐minimal medium, but not in Luria–Bertani broth, and it is shown that flagellar‐mediated motility is required for biofilm Formation in both rich and minimal environments.
Journal ArticleDOI
Genetic analyses of bacterial biofilm formation
Leslie A. Pratt,Roberto Kolter +1 more
TL;DR: These findings are leading to an understanding of the steps involved in initiating biofilm formation and the cellular components required to accomplish these steps.