Author
Lester E. Wold
Bio: Lester E. Wold is an academic researcher. The author has contributed to research in topics: Thrombophlebitis & Vascular disease. The author has an hindex of 2, co-authored 2 publications receiving 147 citations.
Topics: Thrombophlebitis, Vascular disease, Edema
Papers
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TL;DR: There is little in the literature on abnormal localized depositions of body fat to clarify the syndrome of lipedema of the legs, but two of us (E. V. and E. A. H.) described it in 1940.
Abstract: Excerpt There is little in the literature on abnormal localized depositions of body fat to clarify the syndrome of lipedema of the legs which two of us (E. V. A. and E. A. H.) described in 1940.1Co...
188 citations
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TL;DR: A complication observed while giving histamine intra-arterially in the treatment of peripheral vascular disease is reported.
Abstract: Excerpt The purpose of this presentation is to report a complication observed while giving histamine intra-arterially in the treatment of peripheral vascular disease. The treatment of obliterative ...
2 citations
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TL;DR: It is proposed that lipedema is a genetic condition with either X‐linked dominant inheritance or more likely, autosomal dominant inheritance with sex limitation, and appears to be a condition almost exclusively affecting females, presumably estrogen‐requiring as it usually manifests at puberty.
Abstract: Lipedema is a condition characterized by swelling and enlargement of the lower limbs due to abnormal deposition of subcutaneous fat. Lipedema is an under-recognized condition, often misdiagnosed as lymphedema or dismissed as simple obesity. We present a series of pedigrees and propose that lipedema is a genetic condition with either X-linked dominant inheritance or more likely, autosomal dominant inheritance with sex limitation. Lipedema appears to be a condition almost exclusively affecting females, presumably estrogen-requiring as it usually manifests at puberty. Lipedema is an entity distinct from obesity, but may be wrongly diagnosed as primary obesity, due to clinical overlap. The phenotype suggests a condition distinct from obesity and associated with pain, tenderness, and easy bruising in affected areas.
169 citations
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TL;DR: In this article, lymphatic decongestive therapy, medications and supplements are recommended to reduce the abnormal subcutaneous adipose tissue (SAT) of rare adipose disorders.
Abstract: Rare adipose disorders (RADs) including multiple symmetric lipomatosis (MSL), lipedema and Dercum's disease (DD) may be misdiagnosed as obesity. Lifestyle changes, such as reduced caloric intake and increased physical activity are standard care for obesity. Although lifestyle changes and bariatric surgery work effectively for the obesity component of RADs, these treatments do not routinely reduce the abnormal subcutaneous adipose tissue (SAT) of RADs. RAD SAT likely results from the growth of a brown stem cell population with secondary lymphatic dysfunction in MSL, or by primary vascular and lymphatic dysfunction in lipedema and DD. People with RADs do not lose SAT from caloric limitation and increased energy expenditure alone. In order to improve recognition of RADs apart from obesity, the diagnostic criteria, histology and pathophysiology of RADs are presented and contrasted to familial partial lipodystrophies, acquired partial lipodystrophies and obesity with which they may be confused. Treatment recommendations focus on evidence-based data and include lymphatic decongestive therapy, medications and supplements that support loss of RAD SAT. Associated RAD conditions including depression, anxiety and pain will improve as healthcare providers learn to identify and adopt alternative treatment regimens for the abnormal SAT component of RADs. Effective dietary and exercise regimens are needed in RAD populations to improve quality of life and construct advanced treatment regimens for future generations.
123 citations
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TL;DR: This continuing education activity is intended for physicians and nurses with an interest in skin and wound care to enhance the learner's competence in caring for patients with lipedema through understanding the differential diagnoses, pathophysiology, and treatment/management options.
Abstract: Purpose To enhance the learner's competence in caring for patients with lipedema through understanding the differential diagnoses, pathophysiology, and treatment/management options. Target audience This continuing education activity is intended for physicians and nurses with an interest in skin and wound care. Objectives After participating in this educational activity, the participant should be better able to: 1. Differentiate lipedema from other similar diagnoses. 2. Tell patients with lipedema and their caregivers about treatment of this condition. 3. Construct assessments, treatment plans, and management options for patients with lipedema.
112 citations
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TL;DR: The current knowledge of the mechanisms by which defective lymphatics contribute to obesity and fat accumulation in mouse models are reviewed, as well as the understanding of the lymphatic-adipose tissue relationship is reviewed.
112 citations
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TL;DR: Clinical manifestations, pathogenesis, technical investigations, management and therapies of lipoedema are described, with the aim of optimizing management and care of patients with lipoingema.
Abstract: Lipoedema is an infrequently recognized disorder in women. Lipoedema is characterized by bilateral enlargement of the legs due to abnormal depositions of subcutaneous fat associated with often mild oedema. There is substantial variability in disease severity. The diagnosis should be made as early as possible to prevent complications of the disorder, which is associated with increasing functional and cosmetic morbidity. This review describes clinical manifestations, pathogenesis, technical investigations, management and therapies of lipoedema, with the aim of optimizing management and care of patients with lipoedema.
107 citations