The invention relates to a nitrogen-doped titanium oxide coating and a preparation method and application thereof. The nitrogen-doped titanium oxide coating has a porous structure, and the doping quantity of nitrogen elements is 0.5 at%-10at%.

Nitrogen-doped titanium oxide coating and preparation method and application thereof

The invention discloses a ZIF-8@antibacterial ionic coating prepared on the surface of a metal medical implant material and a preparation method of the ZIF-8@antibacterial ionic coating, and belongs to the technical field of biological materials. Antibacterial ions (Sr , Mg , Ag and Cu ) and zeolite imidazolate framework structure materials (ZIFs) are effectively combined and successfully compounded on the surface of a metal medical implant material substrate. Due to the fact that the metal medical implant material substrate has good biocompatibility, the ZIF-8@antibacterial ion coating doped with the antibacterial ions is prepared on the surface of the metal medical implant material substrate, the advantages of the three components are successfully combined, and therefore, thecomposite material has the antibacterial effect while having relatively high biological activity. And the ZIF-8@antibacterial ionic coating prepared by the method is uniformly dispersed on the surface of the metal medical implant material, has good affinity with water, and is beneficial to adhesion of osteoblasts on the surface of the metal medical implant material. By changing the types of dopedatoms, the antibacterial effect of the material under specific conditions can be maximized, and human cells are not damaged.

ZIF-8@antibacterial ionic coating prepared on surface of metal medical implant material and preparation method of ZIF-8@antibacterial ionic coating

The invention is applicable to the field of biomedical materials, and provides a method for improving the biological activity of a titanium alloy material, the titanium alloy material and application.The method comprises the following steps: preprocessing a titanium alloy material; and injecting the temperature-sensitive collagen doped with the bone morphogenetic protein 9 into pores of the preprocessed titanium alloy material, wherein the titanium alloy material is a 3D printed porous titanium alloy material. The temperature-sensitive collagen doped with the bone morphogenetic protein 9 is implanted into pores and the surface of the 3D printing porous titanium alloy material, the temperature-sensitive collagen is used as a carrier for providing controlled release of the bone morphogeneticprotein 9, the biological activity of the surface of the titanium alloy material can be enhanced, and the bone ingrowth and osseointegration capacity of the titanium alloy material can be effectivelyimproved.

Method for improving biological activity of titanium alloy material, titanium alloy material and application

The invention discloses a preparation method of a graphene oxide composited titanium-based medical material. The preparation method comprises the following steps: (1) putting graphene oxide into deionized water or ethanol, carrying out ultrasonic treatment, and carrying out freeze drying, so as to obtain graphene oxide powder; (2) carrying out ball milling on the graphene oxide powder and titanium-based powder, so as to obtain mixed powder, (3) carrying out 3D printing on the mixed powder, so as to obtain a porous composite material; (4) carrying out stress relief annealing on the porous composite material; and (5) forming micro-nano holes in the surface of the porous composite material, so as to obtain the graphene oxide composited titanium-based medical material. By introducing the graphene oxide, the excellent mechanical properties of the graphene oxide composited titanium-based medical material are guaranteed, and by forming the micro-nano holes, rapid synostosis is generated between the graphene oxide composited titanium-based medical material and peripheral bone tissues, so that the applicability of the graphene oxide composited titanium-based medical material is improved.

Preparation method of graphene oxide composited titanium-based medical material

The disclosure provides a hemostatic compound, the hemostatic compound comprises molecular sieves and a fiber, and the molecular sieves are distributed on the fiber surface of the fiber and directly contact the fiber surface. The particle diameter D90 of the molecular sieves is 0.01 to 50 µm, the particle diameter D50 of the molecular sieves is 0.005 to 30 µm. The adhesive content of the contact surface between the molecular sieve and the fiber is zero. The surface of molecular sieve contacted with the fiber is an inner surface, and the inner surface is a rough planar surface, and growth-matched coupling is formed between the molecular sieve and the fiber on the inner surface of the molecular sieve. The surface of molecular sieve uncontacted with the fiber is an outer surface, and the outer surface is non-planar surface. Both the inner surface and outer surface are composed of molecular sieve nanoparticles. The disclosure also provides a preparation method and application of the hemostatic compound. The hemostatic compound of the present disclosure does not need to add an adhesive. And it speeds up the coagulation reaction and plays a role of rapid coagulation, and eliminates the problem that the molecular sieve easily falls off the fiber surface, eradicates the problem that the hemostatic compound easily loses the hemostatic effect, solves the problem that some detachable molecular sieves will adhere to the wound and cause thrombosis, and finally improves the performance and safety of the hemostatic compound.

Hemostatic complex and preparation method therefor

The invention relates to a method for preparing a molecular sieve coating layer on a surface of medical magnesium alloy, belongs to the technical field of preparation of the molecular sieve coating layer on the surface of biomedical implant material magnesium alloy, in particular relates to a method for preparing the molecular sieve coating layer with an ion exchange capacity and an anticorrosive capacity on the surface of medical magnesium alloy by using an in-situ growth method, so that the magnesium alloy has good biological compatibility, corrosion resistance and ion exchangeability to realize the application of the composite material in the aspects such as biomedicine. The method provided by the invention is adopted to prepare the anticorrosive molecular sieve coating layer with the ion exchange capacity on the surface of the magnesium alloy through the in-situ growth method for the first time, has the advantages that the preparation conditions are mild, the uniform coating layer can be prepared on the surface of a complex magnesium alloy substrate, the molecular sieve coating layer has good anticorrosive capacity and the corrosion speed of the magnesium alloy can be effectively slowed down, and can improve the application of the composite material in the aspects such as biomedicine.

Method for preparing molecular sieve coating layer on surface of medical magnesium alloy

The invention discloses a method for rapidly introducing function ions on the surface of titanium alloy, and belongs to the technical field of titanium alloy medical plant material surface functionalization modified treatment. The method comprises the steps that firstly, TC4 is adopted as an electrolytic anode, an electrolytic cell is adopted as an electrolytic cathode, and a volcano shaped porouscoating is formed on the surface of a TC4 sample through the plasma high temperature and high pressure transient sintering effect; then, a hydrothermal reaction method is used for introducing function ions into the coating, and meanwhile, the hydrophilicity is improved. The various function ions are evenly distributed on the surface of titanium alloy, and the adhesion and proliferation capabilityof osteogenesis cells is improved. According to the method, the coating can be prepared on the surface of the titanium alloy conveniently and rapidly, the ingredient of a solution is regulated in thefollow-up hydrothermal process, the function ions of Cu, Zn, Mg, Ce, Sr and the like are introduced to the surface of the coating, antibacterial or osteogenesis and other performances of a biologicalmedical metal material are improved, and the good application prospect is achieved in the fields of surface modification of medical implant materials and the like.

Method for rapidly introducing function ions on surface of titanium alloy

The invention provides a preparation method of a medical implant material surface function atom doped molecular sieve layer and belongs to the technical field of preparation of the molecular sieve layer having high biological activity. New-generation medical implant alloy materials (a bone repair material, a dental implant material and a cardiovascular implant material) having low elasticity modulus and high biocompatibility are used as a substrate, a Silicalite-1 type molecular sieve layer doped with different function atoms grows on the surface of the substrate by means of a co-synthesis method, and accordingly the biological activity, corrosion resistance and bone growing induction capacity of a composite material is improved. The preparation method is suitable for various low-elasticity-modulus medical implant materials, has the advantages of being moderate in preparation conditions, simple in process, low in cost and the like, can be applied to implant materials of any shapes and surface roughness and shows the potential of further development of novel hard-tissue implant materials.

Li Dongdong

Papers

Method for preparing molecular sieve coating layer on surface of medical magnesium alloy

Method for rapidly introducing function ions on surface of titanium alloy

Preparation method of medical implant material surface function atom doped molecular sieve layer