LI Jiexia

Bio: LI Jiexia is an academic researcher. The author has an hindex of 1, co-authored 1 publications receiving 3 citations.

Clinical Research on Treating Functional Dyspepsia with Added Xiaoyao Power

Abstract: Objective: To investigate the curative effect and fitted syndrome of added Xiaoyao power on treating functional dyspepsia(FD). Methods:102 cases with FD were randomly divided into 3 groups: integration of Chinese and western medicine group, T.C.M. group and medicine group. The medicine group was treated with medicine simply, the T.C.M. group with added Xiaoyao power simple, the first group with both medicine and T.C.M. The treatment period was 2 weeks in all three groups.Results: The effective rate in the integration T.C.M. and medicine group was 90.48%, which was significantly higher than those in the medicine group(73.33%) or T.C.M group(70.00%), whose difference was obviousiy(P0.05). Conclusion:Added Xiaoyao power can significantly promote the curative effect on treating FD.

Chinese herbal medicine modified xiaoyao san for functional dyspepsia: meta-analysis of randomized controlled trials.

Abstract: Background: To critically assess the evidence of modified xiaoyao san (MXS) for treating functional dyspepsia (FD). Methods: Systematic literature searches were carried out on the Medline database, CNKI database, Wanfang Data, VIP Information and the Cochrane Library. Reference lists located were checked for further relevant publications. Experts in the field and manufacturers of identified products were contacted for unpublished material. Studies were selected according to predefined inclusion and exclusion criteria. All randomized clinical trials of MXS for treating FD were included. Study selection, data extraction and validation were carried out by at least two reviewers with disagreements being settled by discussion. Weighted means and 95% confidence intervals were calculated and sensitivity analyses were carried out. Results: Thirty-three potentially relevant articles were retrieved for further evaluation. Fourteen were suitable for inclusion in the meta-analysis. There was evidence that MXS compared with prokinetic drugs reduced symptoms (odds ratio 3.26, 95% CI 2.24 to 4. 47). There was evidence that MXS + prokinetic drugs compared with prokinetic drugs reduced symptoms (odds ratio 4.32, 95% CI 2.64 to 7.08). Conclusion: MXS appears to be more effective compared to prokinetic drugs in the treatment of FD and no serious side-effects were identified. However, the evidence remains weak due to publication bias and methodological flaws, which may amplify the therapeutic benefit of MXS.

Pharmacokinetic comparison of puerarin after oral administration of Jiawei-Xiaoyao-San to healthy volunteers and patients with functional dyspepsia: influence of disease state.

Abstract: Objectives An investigation has been designed and conducted to compare the pharmaco-kinetics of puerarin after oral administration of Jiawei-Xiaoyao-San to healthy volunteers and to patients with functional dyspepsia. Methods Quantification of puerarin in serum was achieved using a simple and rapid HPLC method for pharmacokinetic study. Key findings After oral administration of decoctions of Jiawei-Xiaoyao-San to healthy volunteers and patients with functional dyspepsia, puerarin was absorbed and reached a maximum concentration of 56.47 ± 15.60 and 29.40 ± 8.89 ng/ml at 51.00 ± 8.22 and 50.00 ± 12.25 min, respectively. Compared with the value of AUC0–360 (5.55 ± 1.47 μg/ml min) in healthy volunteers, a smaller value of AUC0–360 (3.35 ± 1.17 μg/ml min) was observed in patients with functional dyspepsia. Conclusions There were statistically significant differences in the pharmacokinetic parameters of puerarin including the values for Cmax, AUC0–360, Cl/F and MRT0–360 between healthy volunteers and patients with functional dyspepsia. The pharmacokinetic parameters showed that functional dyspepsia reduced the absorption of puerarin after oral administration of Jiawei-Xiaoyao-San.

Simultaneous Ultra Performance Liquid Chromatography (UPLC) analysis of five components in Fructus aurantii-type formulae

Abstract: A simple, rapid and sensitive liquid chromatographic method has been established for simultaneous analysis of five compounds (narirutin, hesperidin, naringin, neohesperidin and meranzin hydrate) in Fructus aurantii-type preparations. The compounds were separated in less than 12 min using a C18 column with gradient elution using (A) acetonitrile, (B) water and (C) acetic acid at a flow rate of 0.3 ml/min and with a PDA detector. The method was validated for specificity, accuracy, precision and limits of detection. Good linear regression data (r2 > 0.9980) were obtained for all the calibration plots within the ranges tested. The method is an attractive alternative for quality control and clinical monitor of F. aurantii -type preparations. Key words: Fructus aurantii, formulae, chemical compounds, UPLC-PDA.