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Author

Li Lin

Bio: Li Lin is an academic researcher from Dongguan University of Technology. The author has contributed to research in topics: Wacker process & Heterogeneous catalysis. The author has an hindex of 1, co-authored 5 publications receiving 4 citations.

Papers
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Journal ArticleDOI
TL;DR: The resulting Ag@UCPP as a heterogeneous catalyst exhibited excellent activity for the carboxylative cyclization of propargyl alcohols with CO2 under mild conditions, together with good recyclability, probably attributed to the synergistic effect of the UCPP on the adsorption and activation of CO2 and the immobilization of Ag nanoparticles.
Abstract: A dual-functional urea-linked conjugated porous polymer (UCPP) assembled by enol–imine with ordered unit arrays that act as potential anchoring sites in the networks was fabricated, and was further applied as a support for Ag nanoparticles by the coordinate interaction between them. The UCPP not only can well confine the Ag particle size and facilitate high dispersion, but also can afford special CO2-philic moieties to enhance the adsorption properties. The resulting Ag@UCPP as a heterogeneous catalyst exhibited excellent activity for the carboxylative cyclization of propargyl alcohols with CO2 under mild conditions, together with good recyclability, which is probably attributed to the synergistic effect of the UCPP on the adsorption and activation of CO2 and the immobilization of Ag nanoparticles. This work affords possible opportunities for the design and synthesis of a heterogeneous catalyst toward CO2 conversion.

9 citations

Patent
11 Dec 2018
TL;DR: In this article, a novel method for synthesizing entecavirus was proposed, which takes a compound with a known formula 9 as a starting raw material, and a target molecule is synthesized through a series of reactions including a Morita-Baylis-Hillman reaction, a Sharpless asymmetric epoxidation reaction, TBSCl hydroxyl protection, an opening epoxication reaction, tbsCl hyclic protection, a step of reducing carbonyl into double bonds, SeO2 one-step oxidization double-bond alpha-site
Abstract: The invention discloses a novel method for synthesizing entecavir. The novel method takes a compound with a known formula 9 as a starting raw material, and a target molecule is synthesized through a series of reactions including a Morita-Baylis-Hillman reaction, a Sharpless asymmetric epoxidation reaction, TBSCl hydroxyl protection, an opening epoxidation reaction, TBSCl hydroxyl protection, a step of reducing carbonyl into double bonds, SeO2 one-step oxidization double-bond alpha-site H ketone formation reaction, a step of reducing ketone into hydroxyl through lithium triethylborohydride andthe like. The design of a whole route is unique and novel; a reaction process has mild reaction conditions and a rapid speed; side reactions are relatively few and the operation is simple and convenient; conventional chemical reagents are utilized in the route; the raw material is cheap and easy to obtain and the synthesis cost can be greatly reduced.
Patent
11 Feb 2020
TL;DR: In this article, a new synthesis route for cephalotaxine was proposed, which has the advantages of unique and novel design of the synthesis route, mild conditions of the reaction process, high speed, few side reactions, simplicity in operation, and realization of cheap and easily available raw materials and great reduction of synthesis cost due to conventional chemical reagents.
Abstract: The invention discloses a synthesis method of a natural product cephalotaxine. The purpose of the invention is to provide a brand new synthesis route. Sodium cyclopentadienylide used as an initial rawmaterial undergoes key reaction steps such as a hydroboration oxidation reaction, an iodide ion induced N heterocyclic ring construction reaction and a palladium-catalyzed coupling ring closing reaction to finally achieve formalized synthesis of the natural product cephalotaxine. The method has the advantages of unique and novel design of the synthesis route, mild conditions of the reaction process, high speed, few side reactions, simplicity in operation, and realization of cheap and easily available raw materials and great reduction of the synthesis cost due to conventional chemical reagentsutilized in the route.
Patent
22 Feb 2019
TL;DR: In this paper, a novel synthesis method of a natural product isomer (-)-6-epi-Porantheridine is presented, where a target molecule is synthesized by using a compound known in the formula 1 as a starting material through boc t-butoxycarbonyl protection and a series of reaction such as the asymmetric addition reaction of lewis acid catalysis, the Wacker oxidation reaction and ring-closing reaction.
Abstract: The invention discloses a novel synthesis method of a natural product isomer (-)-6-epi-Porantheridine. A target molecule is synthesized by using a compound known in the formula 1 as a starting material through boc t-butoxycarbonyl protection and a series of reaction such as the asymmetric addition reaction of lewis acid catalysis, the Wacker oxidation reaction and ring-closing reaction. The designof the whole route of the invention is unique and novel; the novel synthesis method is mild in reaction process and reaction conditions and fast in rate, has relatively little side reaction, and is simple and convenient in operation; conventional chemical reagents are utilized in the route; the raw materials are cheap and easily available; and the synthesis cost can be greatly reduced.
Patent
04 Jan 2019
TL;DR: In this paper, a novel synthesis method of a natural product (-)-Porantheridine, a compound shown in a known formula 1 is taken as the starting material, and a target molecule is synthesized through a series of reactions of MHorner-Wadsworth-Emmons reaction, N-Michael reaction, Pd (II) catalyzed Wacker oxidization reaction and cyclization under the protection of a tertiary butyl carbonyl.
Abstract: The invention discloses a novel synthesis method of a natural product (-)-Porantheridine, a compound shown in a known formula 1 is taken as the starting material, and a target molecule is synthesizedthrough a series of reactions of MHorner-Wadsworth-Emmons reaction, N-Michael reaction, Pd (II) catalyzed Wacker oxidization reaction and cyclization under the protection of a tertiary butylcarbonylThe design of the whole route is unique and novel, the reaction condition of the reaction process is mild, the speed is high, side effects are relatively few, the operation is convenient, the conventional chemical agent is used in the route, raw materials are cheap and easy to get, and the synthesis cost is greatly lowered

Cited by
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Journal ArticleDOI
TL;DR: This is the first sample that noble-metal-free catalyst can catalyze both propargylic alcohols and propargYlic amines with CO 2 simultaneously, and it can effectively catalyze the cyclization of both prop Argentylic Alcohols and Propargy Lic amineswith CO 2 into valuable α-alkylidene cyclic carbonates and oxazolidinones.
Abstract: The cyclization reactions of propargylic alcohols and propargylic amines with CO 2 are important in industrial applications, but it was great challenge that non-noble-metal catalysts catalyzed both reactions under mild conditions. Herein, the catalyst Cu 2 O@ZIF-8 was prepared by encapsulating Cu 2 O nanoparticles into robust ZIF-8, and it can effectively catalyze the cyclization of both propargylic alcohols and propargylic amines with CO 2 into valuable α-alkylidene cyclic carbonates and oxazolidinones with the turnover number (TON) of 12.1 and 19.6, which can be recycled at least five times. The mechanisms were further uncovered by NMR, FTIR, 13 C isotope labeling experiments and DFT calculations, in which Cu 2 O and DBU can synergistically activate the C≡C bond and the hydroxy/amino group of substrates. Importantly, it is the first sample that noble-metal-free catalyst can catalyze both propargylic alcohols and propargylic amines with CO 2 simultaneously.

13 citations

Journal ArticleDOI
TL;DR: In this paper, a hollow microporous organic polymer (H-MOP-A) with activated internal alkynes as IR probes can be prepared by template synthesis based on acyl Sonogashira-Hagihara coupling at room temperature.
Abstract: This work shows that hollow microporous organic polymer (H-MOP-A) with activated internal alkynes as IR probes can be prepared by template synthesis based on acyl Sonogashira-Hagihara coupling at room temperature. The H-MOP-A is a versatile platform in the main chain PSM based on nonradical thiol-yne click reaction. Moreover, an IR peak of internal alkynes in the H-MOP-A is very intense and could be utilized in the monitoring of thiol-yne click-based main chain PSM. The functionalized H-MOP-A with carboxylic acids (H-MOP-CA) showed efficient adsorption toward Ag + ions. The resultant H-MOP-CA-Ag showed excellent performance in the CO 2 fixation to α-alkylidene cyclic compounds.

6 citations

Journal ArticleDOI
TL;DR: In this paper, a mesoporous NH2-MIL-101(Cr) spherical shell with open pore was used for the synthesis of composite catalysts for carbon dioxide with epichlorohydrin to produce cyclic carbonate.

6 citations

Journal ArticleDOI
TL;DR: In this article, the authors compared the catalytic performance of Zn (II) complexes applied as the efficient catalysts in accelerating the transformation of CO2 into cyclic carbonates.

5 citations

Journal ArticleDOI
01 Dec 2022-Fuel
TL;DR: In this paper , a poly(ionic liquid)s catalyst with dual functions of adsorption and activation was proposed to reduce the energy consumption of CO2 purification, and the highly polar surface and highly dispersed active phase of [email protected]2 facilitated the carboxylative cyclization and hydration of propargylic alcohols with exclusive chemoselectivity under low pressure and concentration of CO 2 (1 bar, 15 % CO2 in 85 % N2, v/v simulated flue gas).

3 citations