L
Li Xia
Researcher at University of North Carolina at Chapel Hill
Publications - 11
Citations - 6405
Li Xia is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Histone methyltransferase & Histone code. The author has an hindex of 10, co-authored 10 publications receiving 5965 citations. Previous affiliations of Li Xia include Howard Hughes Medical Institute.
Papers
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Journal ArticleDOI
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
Ru Cao,Liangjun Wang,Hengbin Wang,Li Xia,Hediye Erdjument-Bromage,Paul Tempst,Richard S. Jones,Yi Zhang +7 more
TL;DR: The purification and characterization of an EED-EZH2 complex, the human counterpart of the Drosophila ESC-E(Z) complex, is reported, and it is demonstrated that the complex specifically methylates nucleosomal histone H3 at lysine 27 (H3-K27).
Journal ArticleDOI
Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor
Hengbin Wang,Zhi-Qing Huang,Li Xia,Qin Feng,Hediye Erdjument-Bromage,Brian D. Strahl,Scott D. Briggs,C. David Allis,Jiemin Wong,Paul Tempst,Yi Zhang +10 more
TL;DR: A mutation in theS-adenosyl-l-methionine–binding site of PRMT1 substantially crippled its nuclear receptor coactivator activity and indicates that Arg 3 methylation plays an important role in transcriptional regulation.
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Purification and Functional Characterization of a Histone H3-Lysine 4-Specific Methyltransferase
Hengbin Wang,Ru Cao,Li Xia,Hediye Erdjument-Bromage,Christoph H. Borchers,Paul Tempst,Yi Zhang +6 more
TL;DR: The purification, molecular identification, and functional characterization of an H3-lysine 4-specific methyltransferase (H3-K4-HMTase), SET7, are reported, which demonstrate that SET7 methylates H2K4 in vitro and in vivo and inhibit each other.
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Tudor, MBT and chromo domains gauge the degree of lysine methylation
Jeesun Kim,Jeremy J. Daniel,Alexsandra Espejo,Aimee Lake,Murli Krishna,Li Xia,Yi Zhang,Mark T. Bedford +7 more
TL;DR: These studies expose tudor and MBT domains as new classes of methyl‐lysine‐binding protein modules, and demonstrates that protein‐domain microarrays are powerful tools for the identification of new domain types that recognize histone modifications.
Journal ArticleDOI
Purification and Functional Characterization of SET8, a Nucleosomal Histone H4-Lysine 20-Specific Methyltransferase
Jia Fang,Qin Feng,Carrie S. Ketel,Hengbin Wang,Ru Cao,Li Xia,Hediye Erdjument-Bromage,Paul Tempst,Jeffrey A. Simon,Yi Zhang +9 more
TL;DR: Although H4-K20 methylation does not correlate with gene activity, it appears to be regulated during the cell cycle and is demonstrated to have an essential role in Drosophila development.