Liam Anuj O’Leary

TL;DR: It is demonstrated that NMDA receptors are present on neural progenitor cells and that human mutations in GRIN2B can impair calcium influx and membrane depolarization even in a presumed undifferentiated cell state, highlighting an important role for non-synaptic NMDA receptor.

TL;DR: In this article, a review of the general properties of human astrocytes, the methods to study them, and the postmortem evidence for brain pathology in major depressive disorder (MDD) was presented.

TL;DR: In this article, the diversity of microglial phenotype and function in health and psychiatric disease was discussed and microglia involvement in major depressive disorder, schizophrenia and bipolar disorder, with a particular focus on post-mortem studies.

TL;DR: It is shown that Cx30 expression localized onto OL cells and myelinated fibers is decreased in deep cortical layers of the ACC in male-depressed suicides, providing a first evidence of impaired AS/OL GJ-mediated communication in the ACC of individuals with mood disorders.

TL;DR: Comparisons of the densities of vimentin-immunoreactive (VIM-IR) and GFAP-IR astrocytes in various brain regions from male individuals having died suddenly in the absence of neurological or psychiatric conditions reveal special features displayed uniquely by human VIM-iris, and illustrate that astroCytes display important region- and marker-specific differences in the healthy human brain.