Liang Chengyuan

TL;DR: The present review surveys the pharmacological advantages and deficiencies of both reversible and irreversible BTK drugs, with a focus on the structure-activity relationship (SARs) and binding modes of representative drugs, which could inspire critical thinking and new ideas for developing potent BTK inhibitors with less unwanted off-target effects.

TL;DR: This review describes the promising RdRp inhibitors that have been launched or are currently in clinical studies for the treatment of RNA virus infections and suggests more precise guidelines for the development of more promising anti-RNA virus drugs should be set.

TL;DR: 3CLpro PROTAC degraders are hypothesised to be next-generation anti-coronavirus drugs based on the emerging PROTAC technology and the existing 3CLpro inhibitors.

TL;DR: A comprehensive insight is offered into the pharmacological activities of GLTs and their potential applications in the development of functional foods and nutraceuticals and the specific relationship between autophagy and apoptosis induced by ganoderic acid DM is summarized here for the first time.

TL;DR: This review presents comprehensive information on remdesivir, including information regarding the milestones, intellectual properties, anti-coronavirus mechanisms, preclinical research and clinical trials, and in particular, the chemical synthesis, pharmacology, toxicology, pharmacodynamics and pharmacokinetics of remdesvir.