L
Liguo Wang
Researcher at Tsinghua University
Publications - 3
Citations - 90
Liguo Wang is an academic researcher from Tsinghua University. The author has contributed to research in topics: Cellular differentiation & Teixobactin. The author has an hindex of 2, co-authored 3 publications receiving 35 citations.
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Journal ArticleDOI
Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy.
Liguo Wang,Xuejing Shao,Tianbai Zhong,Yue Wu,Aixiao Xu,Xiuyun Sun,Hongying Gao,Yongbo Liu,Tianlong Lan,Yan Tong,Xue Tao,Wenxin Du,Wei Wang,Yingqian Chen,Ting Li,Xianbin Meng,Haiteng Deng,Bo Yang,Qiaojun He,Meidan Ying,Yu Rao,Yu Rao +21 more
TL;DR: Wang et al. as mentioned in this paper developed first-in-class CDK2-targeted proteolysis-targeting chimeras (PROTACs), which promoted rapid and potent CDK 2 degradation in different cell lines without comparable degradation of other targets.
Journal ArticleDOI
Gram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics.
Yu Zong,Fang Fang,Kirsten J. Meyer,Liguo Wang,Zhihao Ni,Hongying Gao,Kim Lewis,Jing-Ren Zhang,Yu Rao +8 more
TL;DR: A one-pot reaction to conveniently construct the key building block l-allo-Enduracidine in 30-gram scale in just one hour and a convergent strategy to accomplish a gram-scale total synthesis of teixobactin are developed and found two potent analogous.
Journal ArticleDOI
Design, synthesis, and biological evaluation of multiple targeting antimalarials.
Yiqing Yang,Tang Tongke,Tang Tongke,Xiaolu Li,Thomas Michel,Liqin Ling,Liqin Ling,Zhenghui Huang,Maruthi Mulaka,Yue Wu,Hongying Gao,Liguo Wang,Jing Zhou,Brigitte Meunier,Hangjun Ke,Lubin Jiang,Yu Rao +16 more
TL;DR: An extremely potent molecule, RYL-581, is identified, which binds to multiple protein binding sites of P. falciparum simultaneously and kills various drug-resistant strains in vitro and shows good solubility as well as in vivo activity.