L
Liguo Wang
Researcher at Mayo Clinic
Publications - 110
Citations - 8062
Liguo Wang is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Prostate cancer & Cancer. The author has an hindex of 37, co-authored 96 publications receiving 5956 citations. Previous affiliations of Liguo Wang include Beijing Institute of Genomics & Baylor College of Medicine.
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Journal ArticleDOI
RSeQC: quality control of RNA-seq experiments
Liguo Wang,Shengqin Wang,Wei Li +2 more
TL;DR: The RSeQC package is developed to comprehensively evaluate different aspects of RNA-seq experiments, such as sequence quality, GC bias, polymerase chain reaction bias, nucleotide composition bias, sequencing depth, strand specificity, coverage uniformity and read distribution over the genome structure.
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CPAT: Coding-Potential Assessment Tool using an alignment-free logistic regression model
TL;DR: A novel alignment-free method, Coding Potential Assessment Tool (CPAT), which rapidly recognizes coding and noncoding transcripts from a large pool of candidates, and is approximately four orders of magnitude faster than Coding-Potential Calculator and Phylo Codon Substitution Frequencies.
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CrossMap: a versatile tool for coordinate conversion between genome assemblies
TL;DR: CrossMap is a versatile and efficient tool for converting genome coordinates between assemblies, which supports most of the commonly used file formats, including BAM, sequence alignment map, Wiggle, BigWig, browser extensible data, general feature format, gene transfer format and variant call format.
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Intrinsic BET inhibitor resistance in SPOP -mutated prostate cancer is mediated by BET protein stabilization and AKT–mTORC1 activation
Pingzhao Zhang,Dejie Wang,Yu Zhao,Shancheng Ren,Kun Gao,Zhenqing Ye,Shangqian Wang,Chun Wu Pan,Yasheng Zhu,Yuqian Yan,Yinhui Yang,Di Wu,Yundong He,Jun Zhang,Daru Lu,Xiuping Liu,Long Yu,Shimin Zhao,Yao Li,Dong Lin,Yuzhuo Wang,Liguo Wang,Yu Chen,Yinghao Sun,Chenji Wang,Haojie Huang +25 more
TL;DR: It is demonstrated that wild-type SPOP binds to and induces ubiquitination and proteasomal degradation of BET proteins by recognizing a degron motif common among them, and resistance to BET inhibitors in SPOP-mutant prostate cancer can be overcome by combination with AKT inhibitors.
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Recurrent chimeric RNAs enriched in human prostate cancer identified by deep sequencing
TL;DR: The prevalence of chimeric RNAs may allow the limited number of human genes to encode a substantially larger number of RNAs and proteins, forming an additional layer of cellular complexity.