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Lih-Ming Yiin

Bio: Lih-Ming Yiin is an academic researcher from Tzu Chi University. The author has contributed to research in topics: HEPA & Pesticide. The author has an hindex of 14, co-authored 39 publications receiving 714 citations. Previous affiliations of Lih-Ming Yiin include Rutgers University & National Taiwan University.

Papers
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Journal ArticleDOI
TL;DR: The regression analysis, including the three representative dust variables in the equations to predict blood lead concentration, suggests that the seasonality of blood lead levels in children is related to the seasonal distributions of dust lead in the home.
Abstract: We conducted a study to examine seasonal changes in residential dust lead content and its relationship to blood lead in preschool children. We collected blood and dust samples (floors, windowsills, and carpets) to assess lead exposure. The geometric mean blood lead concentrations are 10.77 and 7.66 microg/dL for the defined hot and cold periods, respectively (p < 0.05). Lead loading (milligrams per square meter) is the measure derived from floor and windowsill wipe samples that is most correlated with blood lead concentration, whereas lead concentration (micrograms per gram) is the best variable derived from carpet vacuum samples. The variation of dust lead levels for these three dust variables (floor lead loading, windowsill lead loading, and carpet lead concentration) are consistent with the variation of blood lead levels, showing the highest levels in the hottest months of the year, June, July, and August. The regression analysis, including the three representative dust variables in the equations to predict blood lead concentration, suggests that the seasonality of blood lead levels in children is related to the seasonal distributions of dust lead in the home. In addition, the outdoor activity patterns indicate that children are likely to contact high leaded street dust or soil during longer outdoor play periods in summer. Consequently, our results show that children appear to receive the highest dust lead exposure indoors and outdoors during the summer, when they have the highest blood lead levels. We conclude that at least some of the seasonal variation in blood lead levels in children is probably due to increased exposure to lead in dust and soil.

165 citations

Journal ArticleDOI
TL;DR: Evidence is provided for nurses to use soothing music as a research-based nursing intervention for intensive care unit patients' sleep improvement and for doctors to use non-commercial music on quality of sleep in critically ill patients.
Abstract: Aim The purpose was to examine the effects of non-commercial music on quality of sleep and relaxation indices, including heart rate, mean arterial pressure, and respiratory rate in patients in intensive care units. Background There is currently insufficient scientific knowledge for the effects of music on quality of sleep in critically ill patients. Design A randomized controlled trial. Methods Between January–December 2010, 28 patients aged 39–78 years were randomly assigned to music and control groups. Participants in the music groups listened to non-commercial music for 45 minutes at nocturnal sleep time. In the control group, participants slept with no music. Participants were assessed using vital signs monitors, standardized questionnaire, and polysomnography. Polysomnography sleep was recorded for the first 2 hours of the nocturnal sleep. General estimating equation was applied to analyse data. Findings Participants in the music group had shorter stage N2 sleep and longer stage N3 sleep in the first 2 hours of the nocturnal sleep and improved self-reported sleep quality, compared with those in the control group. The music group patients also had significantly lower heart rates than those in the control group. The intensive care units patients experienced fragmented sleep with a high frequency of awakenings and severe reduction in random eye movement sleep during the first 2 hours of the nocturnal sleep. Conclusion The findings provided evidence for nurses to use soothing music as a research-based nursing intervention for intensive care unit patients' sleep improvement.

88 citations

Journal ArticleDOI
TL;DR: The descriptive statistics showed that the first occurrences of DED were the most for the elderly by age, women by gender, and spring by season, and it is suggested that efficient management and control of traffic emission may lower the probability of D ED occurrence.
Abstract: Dry eye disease (DED) has become a common eye disease in recent years and appears to be influenced by environmental factors. This study aimed to examine the association between the first occurrence of DED, air pollution and weather changes in Taiwan. We used the systematic sampling cohort database containing 1,000,000 insureds of the National Health Insurance of Taiwan from 2004 to 2013, and identified a total of 25,818 eligible DED subjects. Environmental data, including those of air pollutants, temperature and relative humidity, were retrieved from the environmental monitoring stations adjacent to subjects’ locations of clinics as exposure information. We applied the case-crossover design, which used the same subjects experiencing exposures on diagnosis days as cases and those on other days as controls. The descriptive statistics showed that the first occurrences of DED were the most for the elderly by age (53.6%), women by gender (68.9%), and spring by season (25.9%). Multivariate conditional logistic regression analyses indicated that carbon monoxide (CO), nitrogen dioxide (NO2), and temperature were positively associated with DED (p < 0.05), while relative humidity was negatively related (p < 0.001). Because CO and NO2 together are considered a surrogate of traffic emission, which is easier to control than the uprising temperature, it is suggested that efficient management and control of traffic emission may lower the probability of DED occurrence.

59 citations

Journal ArticleDOI
TL;DR: The morphologic analyses showed that the indoor WTC dust/smoke samples were similar to the outdoor WTCdust/sm smoke samples in composition and characteristics but with more than 50% mass in the <53 μm size fraction, in contrast to the outside samples that contained >50% of mass above >53μm.
Abstract: The collapse of the World Trade Center (WTC) on September 11, 2001, generated large amounts of dust and smoke that settled in the surrounding indoor and outdoor environments in southern Manhattan. Sixteen dust samples were collected from undisturbed locations inside two uncleaned buildings that were adjacent to Ground Zero. These samples were analyzed for morphology, metals, and organic compounds, and the results were compared with the previously reported outdoor WTC dust/smoke results. We also analyzed seven additional dust samples provided by residents in the local neighborhoods. The morphologic analyses showed that the indoor WTC dust/smoke samples were similar to the outdoor WTC dust/smoke samples in composition and characteristics but with more than 50% mass in the 50% of mass above >53 microm. Elemental analyses also showed the similarities, but at lower concentrations. Organic compounds present in the outdoor samples were also detected in the indoor samples. Conversely, the resident-provided convenience dust samples were different from either the WTC indoor or outdoor samples in composition and pH, indicating that they were not WTC-affected locations. In summary, the indoor dust/smoke was similar in concentration to the outdoor dust/smoke but had a greater percentage of mass <53 microm in diameter.

53 citations

Journal ArticleDOI
TL;DR: Results for intestinal bioaccessibility of lead provide support for the model default value of 30% lead bioavailability of dust as a reasonable population indicator for dose, but the higher values for gastric bioaccessible of lead appeared to provide an upper bound that approached actual blood lead levels in the children living in the studied homes.
Abstract: Risk assessments for toxicants in environmental media via oral exposure often rely on measurements of total concentration in a collected sample. However, the human digestive system cannot dissolute all of a toxicant present in the binding matrix, and cannot absorb it with nearly 100% efficiency. In vitro bioaccessibility has been developed as a method to estimate oral bioavailability of a toxicant using a physiologically-based extraction procedure. Bioaccessibility measurements are more physiologically relevant than strong acid leaching measurements of concentration. A method for measuring bioaccessible lead in house dust was derived from the bioaccessibility method currently used for heavy metals in contaminated soils. House dust was collected from carpets in typical urban residences. Bioaccessible lead was measured in house dust (<75 microm) from the homes of 15 participants. The bioaccessibility ranged from 52.4% to 77.2% in gastric fluid, and 4.9% to 32.1% in intestinal fluid. House dust samples from five homes were analyzed to assess the relationship among lead bioaccessibility of three particle size fractions (<75, 75-150, and 150-250 microm). Changes in lead bioaccessibility as a function of particle size fraction were not significant for gastric fluid (p= 0.7019); however they were significant for intestinal fluid (p= 0.0067). This decrease of bioaccessibility may result from the readsorption of dissolved lead onto the dust particles or precipitation of lead with phosphates in a high-pH environment. The bioaccessibility data obtained for two biofluids were applied to the IEUBK model, and results for intestinal bioaccessibility of lead provide support for the model default value of 30% lead bioavailability of dust as a reasonable population indicator for dose, but the higher values for gastric bioaccessibility of lead appeared to provide an upper bound that approached actual blood lead levels in the children living in the studied homes. This upper bound seemed to overcome some of the limitations of the model when it lacks child-specific activity data and characterization of all exposure routes.

50 citations


Cited by
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Journal ArticleDOI
TL;DR: Substantial agreement was found among a large, interdisciplinary cohort of international experts regarding evidence supporting recommendations, and the remaining literature gaps in the assessment, prevention, and treatment of Pain, Agitation/sedation, Delirium, Immobility (mobilization/rehabilitation), and Sleep (disruption) in critically ill adults.
Abstract: Objective:To update and expand the 2013 Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the ICU.Design:Thirty-two international experts, four methodologists, and four critical illness survivors met virtually at least monthly. All section groups g

1,935 citations

27 Oct 1991
TL;DR: In this article, the effects of lead poisoning on the developing developing developing nervous system were investigated, including neurological, neurobehavioral, and developmental effects in children, and toxicity.
Abstract: Essentiality Toxicity Carcinogenicity Lead(Pb) Exposure Toxicokinetics Toxicity Neurologic, Neurobehavioral, and Developmental Effects in Children Mechanisms of Effects on the Developing Nervous System Peripheral Neuropathy Hematologic Effects Renal Toxicity Lead and Gout Effects on Cardiovascular System Immunotoxicity Bone Effects Reproductive Effects Birth Outcomes Carcinogenicity Other Effects Dose Response Treatment Organic Lead Compounds Mercury (Hg) Exposure Disposition and Toxicokinetics Metabolic Transformation Cellular Metabolism Toxicology Biological Indicators Treatment Nickel (Ni) Exposure Toxicokinetics Essentiality Toxicity Nickel Carbonyl Poisoning Dermatitis Indicators of Nickel Toxicity

1,727 citations

Journal ArticleDOI
TL;DR: In this article, the authors combine direct empirical evidence with the basic principles of indoor pollutant behavior and with information from relevant studies, to analyze and critically assess air pollutant exposures resulting from the use of cleaning products and air fresheners.

724 citations

Book
01 Jan 1991
TL;DR: The 2001 Budget for the United States Department of Housing and Urban Development (HUD) as mentioned in this paper provides a significant increase in the amount of money available to the Department to provide adequate and affordable housing, economic opportunity, and a suitable living environment.
Abstract: This chapter presents the budget estimates and program justifications for the Department of Housing and Urban Development (HUD). HUD’s core mission is to promote adequate and affordable housing, economic opportunity and a suitable living environment free from discrimination. The 2001 Budget for HUD reflects the successful implementation of a multiyear comprehensive reform effort which has helped restore the effectiveness and financial integrity of the Department’s critical affordable housing and economic development initiatives. Building on the success of these reforms, Congress and the Administration have provided significant increases in key HUD programs over the past two years. The 2001 Budget will continue these historic successes by providing the Department with the tools to fulfill its fundamental strategic goals: increasing the availability of decent, safe and affordable housing in American communities (including the enhancement of homeownership opportunities, especially for minorities and first-time homebuyers, the transformation of public housing and the expansion of housing assistance to alleviate severe housing needs); ensuring equal housing opportunity; promoting self-sufficiency and asset development of families and individuals (including moving homeless families to self-sufficiency through locally-developed continuum of care strategies and contributing to the success of welfare-to-work efforts); and improving community quality of life and economic vitality through locally-driven initiatives and programs. The 2001 budget provides increases for two successful block grant programs which serve HUD’s fundamental affordable housing and economic development missions—the Community Development Block Grant (CDBG) and the HOME Investment Partnerships programs. These programs provide states and localities with formula funding pursuant to locally-developed consolidated plans for a wide variety of activities which benefit low and moderate-income families. The Community Development Loan Guarantee program (under Section 108 of the Housing and Community Development Act of 1974) will be continued with level funding and a slightly increased loan guarantee limitation. The Economic Development Initiative will also be maintained. Grants for Urban Empowerment Zones will continue support for ten-year plans to provide new job opportunities and community revitalization in 15 urban areas. The Rural Housing and Economic Development program will be continued at an increased level. HUD’s Homeless Assistance programs will be funded at an increased level to enable communities to continue their development and implementation of comprehensive coordinated continuum of care systems to address the needs of homeless people and families. This funding includes 18,000 rental assistance vouchers designed to provide affordable permanent housing for formerly homeless individuals and families in order to provide a stable living environment, a critical necessity for maintaining access to needed services and providing access to employment opportunities. HUD’s Continuum of Care approach recently received the prestigious 1999 Innovations in Government award from the Harvard University’s John F. Kennedy School of Government and the Ford Foundation. The 2001 Budget maintains the Federal commitment to replacing distressed and obsolete public housing with attractive, mixed-income communities and creating new economic opportunities for residents. Consistent with this commitment and with a special focus on replacing projects that have been determined to be non-viable, the HOPE VI program will receive a significant increase from last year’s enacted level. The 2001 Budget provides $3,192 million for the Public Housing Operating Fund, which helps to maintain good quality housing, and provides a slight increase for the Public Housing Capital Fund, which helps modernize and improve the housing stock. The 2001 budget includes 120,000 incremental vouchers that will help address the severe housing needs of low-income households. These vouchers are necessary to address the continued increase in the number of families nationwide which have worst case needs for housing assistance, including extremely-low income families currently paying more than half their income for rent or living in severely inadequate living conditions. The Administration reaffirms its long-held commitment to renew all expiring Section 8 contracts, to protect residents from displacement by substantially increasing funding for Section 8 renewals, to provide Section 8 tenant-based assistance for displaced families, and for the replacement of affordable housing due to opt-outs from the project-based Section 8 program. The Administration also continues its support for the Department’s successful Housing for Persons With HIV/AIDS program (HOPWA) by providing increased funding to prevent thousands of persons with HIV/AIDS from becoming homeless. This increase is necessary to continue to provide stable housing and services in existing local programs and fund new jurisdictions as they become eligible for formula funding due to the continued increase in the number of AIDS cases. Building on last year’s successful adoption of the Housing Security Plan for Older Americans, the Housing for the Elderly program (under Section 202 of the Housing Act of 1959) will receive a substantial increase, including an increase in capital funding to convert existing housing to assisted living with services and an increase for construction of new affordable assisted living. The Housing for Persons with Disabilities (under Section 811 of the National Affordable Housing Act of 1990) will receive additional funding. In support of the Administration’s strong commitment to increase homeownership opportunities, the 2001 budget includes major support to help lowand moderate-income American families become homebuyers. The budget will increase the Federal Housing Administration’s (FHA) maximum mortgage loan limits, allowing Single Family insurance to cover loans up to the same level as the Fannie Mae and Freddie Mac (GSEs) limits. (Currently FHA can insure home mortgages only up to 87 percent of the GSE limits in high cost areas and only up to 48 percent in low-cost areas, including approximately 2,200 rural counties throughout the Nation). In addition, the budget authorizes FHA to develop new adjustable rate mortgage products. These provisions will provide much-needed assistance to first-time homebuyers, minorities, and other underserved populations. Increased funding for the Fair Housing Assistance and Fair Housing Initiatives programs (FHAP and FHIP) will strengthen the ability of public and private fair housing groups, and partnerships between them, to enforce the laws protecting all Americans against illegal housing discrimination. In order to ensure the effective implementation of its programs, the Department’s Office of Policy Development and Research (PD&R) will be provided with a budget increase. These additional funds are necessary to ensure timely provision of data, research and analysis of national housing and economic conditions, and to measure the performance of pro-

540 citations