Co-Planar Stereotaxic Atlas of the Human Brain—3-Dimensional Proportional System: An Approach to Cerebral Imaging, J. Talairach, P. Tournoux. Georg Thieme Verlag, New York (1988), 122 pp., 130 figs. DM 268

The phenomenon of empathy entails the ability to share the affective experiences of others. In recent years social neuroscience made considerable progress in revealing the mechanisms that enable a person to feel what another is feeling. The present review provides an in-depth and critical discussion of these findings. Consistent evidence shows that sharing the emotions of others is associated with activation in neural structures that are also active during the first-hand experience of that emotion. Part of the neural activation shared between self- and other-related experiences seems to be rather automatically activated. However, recent studies also show that empathy is a highly flexible phenomenon, and that vicarious responses are malleable with respect to a number of factors--such as contextual appraisal, the interpersonal relationship between empathizer and other, or the perspective adopted during observation of the other. Future investigations are needed to provide more detailed insights into these factors and their neural underpinnings. Questions such as whether individual differences in empathy can be explained by stable personality traits, whether we can train ourselves to be more empathic, and how empathy relates to prosocial behavior are of utmost relevance for both science and society.

/pdf/the-social-neuroscience-of-empathy-51gzjyekxl.pdf

The social neuroscience of empathy

Meta-analytic evidence for common and distinct neural networks associated with directly experienced pain and empathy for pain

How is our self related to midline regions and the default-mode network?

Real-world events unfold at different time scales and, therefore, cognitive and neuronal processes must likewise occur at different time scales. We present a novel procedure that identifies brain regions responsive to sensory information accumulated over different time scales. We measured functional magnetic resonance imaging activity while observers viewed silent films presented forward, backward, or piecewise-scrambled in time. Early visual areas (e.g., primary visual cortex and the motion-sensitive area MT+) exhibited high response reliability regardless of disruptions in temporal structure. In contrast, the reliability of responses in several higher brain areas, including the superior temporal sulcus (STS), precuneus, posterior lateral sulcus (LS), temporal parietal junction (TPJ), and frontal eye field (FEF), was affected by information accumulated over longer time scales. These regions showed highly reproducible responses for repeated forward, but not for backward or piecewise-scrambled presentations. Moreover, these regions exhibited marked differences in temporal characteristics, with LS, TPJ, and FEF responses depending on information accumulated over longer durations (approximately 36 s) than STS and precuneus (approximately 12 s). We conclude that, similar to the known cortical hierarchy of spatial receptive fields, there is a hierarchy of progressively longer temporal receptive windows in the human brain.

/pdf/a-hierarchy-of-temporal-receptive-windows-in-human-cortex-4p5rhnogzo.pdf

A Hierarchy of Temporal Receptive Windows in Human Cortex

Gender difference in empathy for pain: an electrophysiological investigation

Christianity strongly encourages its believers to surrender to God and to judge the self from God's perspective. We used functional MRI to assess whether this religious belief is associated with neural correlates of self-referential processing distinct from that of non-religious people. Non-religious and Christian participants were scanned while performing tasks of personal-trait judgments regarding the self or public persons. We found that, while self-judgment was linked to better memory of traits related to the self than to others, self-referential processing induced increased activity in the ventral medial prefrontal cortex (MPFC) for non-religious participants but in the dorsal MPFC for Christian participants. In addition, the dorsal MPFC activity was positively correlated with the rating scores of the importance of Jesus' judgment in subjective evaluation of a person's personality. Because the ventral and dorsal MPFC are respectively engaged in representation of stimulus self-relevance and evaluation of self-referential stimuli, our findings suggest that Christian beliefs result in weakened neural coding of stimulus self-relatedness but enhanced neural activity underlying evaluative processes applied to self-referential stimuli.

Neural consequences of religious belief on self-referential processing.

Where in the brain are the self and significant others (e.g. mother) represented? Neuroscientists have traced self-representation to the ventral medial prefrontal cortex for both Westerners and East Asians. However, significant others were represented alongside the self in the same brain area for East Asians but not for Westerners. In this experiment, Westernized bicultural Chinese were scanned using functional magnetic resonance imaging while performing trait judgments that referenced the self, mother, or a non-identified person (NIP) after Western or Chinese culture priming. Consistent with Western independent self-construals and Chinese interdependent self-construals, Western priming increased, whereas Chinese priming decreased the neural differentiation of mother and NIP from self.

https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1467-839X.2010.01303.x

Dynamic bicultural brains: fMRI study of their flexible neural representation of self and significant others in response to culture primes

Recent brain imaging studies indicate that empathy for pain relies upon both the affective and/or the sensorimotor nodes of the pain matrix, and empathic neural responses are modulated by stimulus reality, personal experience, and affective link with others. The current work investigated whether and how empathic neural responses are modulated by emotional contexts in which painful stimulations are perceived. Using functional magnetic resonance imaging (fMRI), we first showed that perceiving a painful stimulation (needle penetration) applied to a face with neutral expression induced activation in the anterior cingulate cortex (ACC) relative to nonpainful stimulation (Q-tip touch). However, when observation of the painful stimuli delivered to a neutral face was intermixed with observation of painful or happy faces, the ACC activity decreased while the activity in the face area of the secondary somatosensory cortex increased to the painful stimulation. Moreover, the secondary somatosensory activity associated with the painful stimulation decreased when the painful stimulation was applied to faces with happy and painful expressions. The findings suggest that observing painful stimuli in an emotional context weakens affective responses but increases sensory responses to perceived pain and implies possible interactions between the affective and sensory components of the pain matrix during empathy for pain.

/pdf/empathic-neural-responses-to-others-pain-are-modulated-by-450kijtyd4.pdf

Lihua Mao

Papers

Gender difference in empathy for pain: an electrophysiological investigation

Neural consequences of religious belief on self-referential processing.

Dynamic bicultural brains: fMRI study of their flexible neural representation of self and significant others in response to culture primes

Empathic neural responses to others' pain are modulated by emotional contexts.

Event-related theta and alpha oscillations mediate empathy for pain.