Author
Lik-Cheung Cheng
Bio: Lik-Cheung Cheng is an academic researcher from Tsinghua University. The author has contributed to research in topics: Cardiac Inflammatory Myofibroblastic Tumor. The author has an hindex of 1, co-authored 1 publications receiving 21 citations.
Papers
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TL;DR: The successful treatment of a 2-month-old boy with multiple inflammatory myofibroblastic tumors in the right ventricle protruding into the right atrium through the tricuspid annulus is reported.
22 citations
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TL;DR: A favorable response to crizotinib seen in three cases supports its potential use in infants as seen in older patients and awareness of these unusual morphologic, immunophenotypic, and molecular features is critical for appropriate diagnosis and optimized targeted therapy.
35 citations
TL;DR: A comprehensive review of cardiac IMT is described, including information on nomenclature, epidemiology, clinical features, pathogenesis, gross/histological features, immunohistochemical profile, diagnosis, treatment, and prognosis.
Abstract: Although inflammatory myofibroblastic tumors (IMTs) can be found in virtually every major organ, cardiac origin is rare. After recently providing care to a child who presented with a significant myocardial infarction, interest in this rare tumor was piqued. We describe a comprehensive review of cardiac IMT, including information on nomenclature, epidemiology, clinical features, pathogenesis, gross/histological features, immunohistochemical profile, diagnosis, treatment, and prognosis. Fifty-seven cases were identified in the literature. Interestingly, our case represents the seventh case of coronary artery involvement reported. Moreover, it was found that an initial presentation of sudden death most commonly involves the coronary arteries.
24 citations
TL;DR: The present case showed morphologic and immunohistochemical features characteristic of IMT and the immunoreactivity pattern was similar to that of extracardiac IMTs except for anaplastic lymphoma kinase 1 immunore activity, lacking in this benign intracardiacIMT but usually associated to favourable prognosis in extracardship.
19 citations
TL;DR: A case of cardiac IPT caused by Listeria monocytogenes that evolved following gastroenteritis in a previously healthy child is presented.
18 citations
TL;DR: A 58‐year‐old woman presenting with dyspnea was found to have congestive heart failure due to the invagination of a tumor‐like mass of the mitral valve, suggesting IPT/IMT.
Abstract: We report a rare case of inflammatory pseudotumor/inflammatory myofibroblastic tumor (IPT/IMT) of the heart, involving the mitral valve. A 58-year-old woman presenting with dyspnea was immediately admitted to the hospital, and found to have congestive heart failure due to the invagination of a tumor-like mass of the mitral valve. This mass arose from and involved almost the entire posterior leaflet of the mitral valve and occupied almost the entire mitral valve orifice. The tumor was a yellowish-white well-circumscribed mass with a smooth surface. The excised mass was 3.0 x 2.3 x 1.8 cm, and consisted of abundant Sudan III-positive foam cells, histiocytes, lymphocytes, plasma cells, and loosely arrayed spindle cells, in vascular-rich fibrous tissue. Immunohistochemistry showed that the spindle cells were positive for vimentin and alpha-smooth muscle actin, and negative for desmin, CD34, and human muscle actin (HHF-35), suggesting they were myofibroblastic cells. The plasma cells and lymphocytes showed no monoclonality. There were few mitotic cells, and, except for the lymphocytes, few Ki-67-positive cells. The findings suggested IPT/IMT. The 39 cardiac IPT/IMT cases appearing in the English-language literature are discussed.
17 citations