Author
Likun Fei
Other affiliations: Fudan University
Bio: Likun Fei is an academic researcher from University of Southern California. The author has contributed to research in topics: Internalization & Cell-penetrating peptide. The author has an hindex of 6, co-authored 7 publications receiving 441 citations. Previous affiliations of Likun Fei include Fudan University.
Papers
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TL;DR: Due to the cross-linked O-CMC network, in vitro muco-adhesive force and mechanical properties, including compression and tensile modulus, of the SPH-IPN were greatly improved when compared with the CSPH.
266 citations
TL;DR: In this investigation, superporous hydrogels containing poly (acrylic acid-co-acrylamide)/O-carboxymethyl chitosan (O-CMC) full-interpenetrating polymer networks (SPH-IPNs) were evaluated for their potentials in effective insulin absorption via the oral route and showed pronounced properties that would be a promising peroral carrier for insulin and other peptide drugs.
72 citations
TL;DR: In this article, an interpenetrating polymer network-superporous hydrogel containing sodium alginate (IPN-SPHAlg) was synthesized and the morphology of the polymer was characterized using scanning electron microscopy, light images and porosity, and further examined by swelling ratio, mechanical strength and biocompatibility.
Abstract: In this investigation an interpenetrating polymer network–superporous hydrogel containing sodium alginate (IPN-SPHAlg) was synthesized. The morphology of the polymer was characterized using scanning electron microscopy, light images and porosity, and the polymer was further examined by swelling ratio, mechanical strength and biocompatibility. The results indicated that the IPN-SPHAlg possessed both large numbers of interconnected pores and an interpenetrating network. The swelling ratio of IPN-SPHAlg was lower than that of the superporous hydrogel (SPH) and it decreased as the sodium alginate/monomer ratio increased. The IPN-SPHAlg exhibited pH responsiveness and salt-sensitive properties. Compared to SPH and SPH composites, the mechanical strength of IPN-SPHAlg was significantly enhanced. Thiazolyl blue assay on AD293 cells, in situ lactate dehydrogenase assay and morphological study of rat intestine showed that the polymer induced no significant cell or mucosal damage. The fast swelling, good mechanical properties, pH sensitivity and biocompatibility of the IPN-SPHAlg suggested it as a potential candidate in the field of drug-delivery systems. Copyright © 2007 Society of Chemical Industry
58 citations
TL;DR: Using a xenograft mouse model of human breast cancer, fluorescent imaging showed that only HE-MAP could effectively target GST to the tumor site, while reducing non-specific association of MAP in other organs.
41 citations
TL;DR: A recently designed nanoconstruct was engineered using recombinant technology to contain a cell-penetrating peptide (CPP), i.e. Model Amphipathic Peptide (MAP), attached to a pH-sensitive masking peptide sequence to prevent non-specific internalization of the construct in non-target cells.
31 citations
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TL;DR: Recent progress in overcoming challenges with regards to effectively delivering hydrogels inside the body without implantation, prolonging the release kinetics of drugs fromhydrogels, and expanding the nature of drugs which can be delivered using hydrogel-based approaches is discussed.
3,140 citations
TL;DR: The chemical modification affords a wide range of derivatives with modified properties for specific end use applications in diversified areas mainly of pharmaceutical, biomedical and biotechnological fields.
Abstract: Of late, the most bountiful natural biopolymer chitin and chitosan have become cynosure of all party because of an unusual combination of biological activities plus mechanical and physical properties. However applications of chitin are limited due to its inherent insoluble and intractable nature. Chitosan, alkaline hydrolytic derivative of chitin has better solubility profile, less crystallinity and is amenable to chemical modifications due to presence of functional groups as hydroxyl, acetamido, and amine. The chemical modification of chitosan is of interest because the modification would not change the fundamental skeleton of chitosan, would keep the original physicochemical and biochemical properties and finally would bring new or improved properties. In view of rapidly growing interest in chitosan its chemical aspects and chemical modification studies is reviewed. The several chemical modifications such as oligomerization, alkylation, acylation, quternization, hydroxyalkylation, carboxyalkylation, thiolation, sulfation, phosphorylation, enzymatic modifications and graft copolymerization along with many assorted modifications have been carried out. The chemical modification affords a wide range of derivatives with modified properties for specific end use applications in diversified areas mainly of pharmaceutical, biomedical and biotechnological fields. Assorted modifications including chitosan hybrids with sugars, cyclodextrin, dendrimers, and crown ethers have also emerged as interesting multifunctional macromolecules. The versatility in possible modifications and applications of chitosan derivatives presents a great challenge to scientific community and to industry. The successful acceptance of this challenge will change the role of chitosan from being a molecule in waiting to a lead player.
898 citations
TL;DR: In this paper, the authors give an overview of the recent design concepts of IPN hydrogels and their applications in controlled drug delivery, and separation processes, and a special concern is given to the macroporous IPN composite cryogels, which are very attractive materials for separation processes being endowed with a high reusability.
709 citations
TL;DR: P pH-responsive biomaterials bring forth conformational changes in these nanocarriers through various mechanisms such as protonation, charge reversal or cleavage of a chemical bond, facilitating tumour specific cell uptake or drug release, helping to design more efficient drug delivery systems.
698 citations
TL;DR: This work reviews the state of the art and the most recent advances in the development of wound dressings for DFU treatment, with special emphasis given to systems employing new polymeric biomaterials, and to the latest and innovative therapeutic strategies and delivery approaches.
568 citations