L
Lily Chan
Researcher at Ontario Veterinary College
Publications - 13
Citations - 71
Lily Chan is an academic researcher from Ontario Veterinary College. The author has contributed to research in topics: Medicine & Immune system. The author has an hindex of 2, co-authored 7 publications receiving 8 citations. Previous affiliations of Lily Chan include University of Guelph.
Papers
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Journal ArticleDOI
Cytokine Storm Syndrome in SARS-CoV-2 Infections: A Functional Role of Mast Cells.
Bahareh Hafezi,Lily Chan,Jason P. Knapp,Negar Karimi,Kimia Alizadeh,Yeganeh Mehrani,Byram W. Bridle,Khalil Karimi +7 more
TL;DR: In this article, the authors present evidence that a cytokine response by mast cells may initiate inappropriate antiviral immune responses and cause the development of cytokine storm syndrome, which is a cascade of escalated immune responses disposing the immune system to exhaustion, which might ultimately result in organ failure and fatal respiratory distress.
Journal ArticleDOI
The Roles of Neutrophils in Cytokine Storms
Lily Chan,Negar Karimi,Solmaz Morovati,Kasra Alizadeh,Julia E. Kakish,Sierra Vanderkamp,Fatemeh Fazel,Christina Napoleoni,Kimia Alizadeh,Yeganeh Mehrani,Jessica A. Minott,Byram W. Bridle,Khalil Karimi +12 more
TL;DR: In this article, a review highlights the advances in understanding the mechanisms governing neutrophilic inflammation against viral and bacterial pathogens, in cancers, and in autoimmune diseases, and how neutrophils could influence the development of cytokine storm syndromes.
Journal ArticleDOI
Characterization of the Impact of Oncolytic Vesicular Stomatitis Virus on the Trafficking, Phenotype, and Antigen Presentation Potential of Neutrophils and Their Ability to Acquire a Non-Structural Viral Protein.
Ashley A. Stegelmeier,Lily Chan,Yeganeh Mehrani,Jim Petrik,Sarah K. Wootton,Byram W. Bridle,Khalil Karimi +6 more
TL;DR: This study analyzed how administering the rhabdovirus vesicular stomatitis virus intravenously at 1 × 109 PFU acutely influenced neutrophil populations and implicated neutrophils as major contributors to oncolytic rhabDoviral therapies.
Journal ArticleDOI
Intranasal vaccination with a Newcastle disease virus-vectored vaccine protects hamsters from SARS-CoV-2 infection and disease
Bryce M. Warner,Lisa A. Santry,Alexander Leacy,Mable Chan,Phuc H. Pham,Robert Vendramelli,Yanlong Pei,Nikesh Tailor,Emelissa J. Valcourt,Anders Leung,Shihua He,Bryan D. Griffin,Jonathan Audet,Marnie Willman,Kevin Tierney,Alixandra Albietz,Kathy L. Frost,Jacob G. E. Yates,Robert C. Mould,Lily Chan,Yeganeh Mehrani,Jason P. Knapp,Jessica A. Minott,Logan Banadyga,David Safronetz,David Safronetz,Heidi Wood,Stephanie A. Booth,Pierre Major,Byram W. Bridle,Leonardo Susta,Darwyn Kobasa,Darwyn Kobasa,Sarah K. Wootton +33 more
TL;DR: In this paper, two recombinant Newcastle disease virus (NDV) vectors expressing either the full-length SARS-CoV-2 spike protein or a version with a 19 amino acid deletion at the carboxy terminus were used.
Journal ArticleDOI
Review of Influenza Virus Vaccines: The Qualitative Nature of Immune Responses to Infection and Vaccination Is a Critical Consideration.
Lily Chan,Kasra Alizadeh,Kimia Alizadeh,Fatemeh Fazel,Julia E. Kakish,Negar Karimi,Jason P. Knapp,Yeganeh Mehrani,Jessica A. Minott,Solmaz Morovati,Amira D Rghei,Ashley A. Stegelmeier,Sierra Vanderkamp,Khalil Karimi,Byram W. Bridle +14 more
TL;DR: In this paper, the qualitative nature of immune responses against influenza viruses, with an emphasis on trained immunity and an assessment of the characteristics of the host-pathogen that compromise the effectiveness of immunization.