L
Lin-Lin Zhang
Researcher at Huazhong University of Science and Technology
Publications - 5
Citations - 22
Lin-Lin Zhang is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Autophagy & Human cytomegalovirus. The author has an hindex of 2, co-authored 5 publications receiving 11 citations.
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Journal ArticleDOI
Maternal Murine Cytomegalovirus Infection during Pregnancy Up-regulates the Gene Expression of Toll-like Receptor 2 and 4 in Placenta.
TL;DR: Imbalance of IL-6 expression in placenta might be associated with the neurodevelopmental disorders in progeny, and acute MCMV infection during pregnancy could up-regulate the gene expression of TLR2/4 in placental trophoblasts and activate them to produce more proinflammatory cytokine IL- 6.
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Inhibition of autophagy by 3‐methyladenine restricts murine cytomegalovirus replication
Xinyan Zhang,Lin-Lin Zhang,Yidan Bi,Ting Xi,Zhan Zhang,Yuan Huang,Yuan Yuan Lu,Xing-lou Liu,Sai-nan Shu,Feng Fang +9 more
TL;DR: In this article, the role of autophagy inhibition by 3-methyladenine (3-MA) on murine cytomegalovirus (MCMV) replication and whether it is associated with caspase-3 dependent apoptosis was investigated.
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The role of autophagy in human cytomegalovirus IE2 expression
TL;DR: Whether autophagy regulates the expression of human cytomegalovirus immediately early two viral protein (IE2) is investigated to find one way for autophagic to restrict HCMV replication.
Journal ArticleDOI
Short-lived AIM2 Inflammasome Activation Relates to Chronic MCMV Infection in BALB/c Mice.
Yuanyuan Lu,Xing-lou Liu,Yuan Huang,Yi Liao,Ting Xi,Ya-Nan Zhang,Lin-Lin Zhang,Sai-nan Shu,Feng Fang +8 more
TL;DR: In conclusion, the activation of AIM2 inflammasome in BALB/c mice was short-lived, which is quite possibly related to the chronicity of MCMV infection.
Journal ArticleDOI
The Role of Autophagy in Murine Cytomegalovirus Hepatitis.
TL;DR: In this article, the role of autophagy in MCMV hepatitis was investigated in the liver of BALB/c mice, and the PI3K/Akt/mTOR pathway was inhibited through activating autophagocyte activation in liver of the infected mice.