L
Lin Qi
Researcher at Northwestern University
Publications - 45
Citations - 2086
Lin Qi is an academic researcher from Northwestern University. The author has contributed to research in topics: Cancer & Autophagy. The author has an hindex of 18, co-authored 40 publications receiving 1531 citations. Previous affiliations of Lin Qi include Children's Memorial Hospital & Baylor College of Medicine.
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Journal ArticleDOI
Functionally defined therapeutic targets in diffuse intrinsic pontine glioma
Catherine S. Grasso,Yujie Tang,Yujie Tang,Nathalene Truffaux,Noah E. Berlow,Lining Liu,Marie-Anne Debily,Marie-Anne Debily,Michael J. Quist,Lara E. Davis,Elaine C. Huang,Pamelyn Woo,Anitha Ponnuswami,S. Chen,Tessa Johung,Wenchao Sun,Mari Kogiso,Yuchen Du,Lin Qi,Yulun Huang,Yulun Huang,Marianne Hütt-Cabezas,Katherine E. Warren,Ludivine Le Dret,Paul S. Meltzer,Hua Mao,Martha Quezado,Dannis G. van Vuurden,Jinu Abraham,Maryam Fouladi,Matthew N. Svalina,Nicholas J. Wang,Cynthia Hawkins,Javad Nazarian,Marta M. Alonso,Eric H. Raabe,Esther Hulleman,Paul T. Spellman,Xiao-Nan Li,Charles Keller,Ranadip Pal,Jacques Grill,Jacques Grill,Michelle Monje +43 more
TL;DR: Combination testing of panobinostat and the histone demethylase inhibitor GSK-J4 revealed that the two had synergistic effects, and these data suggest a promising therapeutic strategy for DIPG.
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Synaptopathies: synaptic dysfunction in neurological disorders - A review from students to students
Katarzyna Lepeta,Mychael V. Lourenco,Barbara Schweitzer,Pamela V. Martino Adami,Priyanjalee Banerjee,Silvina Catuara-Solarz,Mario de la Fuente Revenga,Alain M. Guillem,Mouna Haidar,Omamuyovwi M. Ijomone,Bettina Nadorp,Lin Qi,Nirma D Perera,Louise K. Refsgaard,Kimberley M. Reid,Mariam Sabbar,Arghyadip Sahoo,Natascha Schaefer,Rebecca K. Sheean,Anna Suska,Rajkumar Verma,Cinzia Vicidomini,Dean J. Wright,Xingding Zhang,Constanze I. Seidenbecher +24 more
TL;DR: Basic concepts of synapse structure and function are discussed, and a critical view of how aberrant synapse physiology may contribute to neurodevelopmental disorders as well as neurodegenerative disorders are provided.
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HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC-Driven Medulloblastoma
Yanxin Pei,Yanxin Pei,Kun Wei Liu,Jun Wang,Alexandra Garancher,Ran Tao,Lourdes Adriana Esparza,Donna L. Maier,Yoko T. Udaka,Najiba Murad,Sorana Morrissy,Huriye Seker-Cin,Sebastian Brabetz,Lin Qi,Mari Kogiso,Simone Schubert,James M. Olson,Yoon Jae Cho,Xiao-Nan Li,John R. Crawford,Michael J. Levy,Marcel Kool,Stefan M. Pfister,Michael D. Taylor,Robert J. Wechsler-Reya +24 more
TL;DR: These studies identify an effective combination therapy for the most aggressive form of MB, which combines histone deacetylase inhibitors with phosphatidylinositol 3-kinase inhibitors to inhibit tumor growth in vivo.
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Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells
Fengtao You,Licui Jiang,Bozhen Zhang,Qiang Lu,Qiao Zhou,Xiaoyang Liao,Hong Wu,Kaiqi Du,Youcai Zhu,Huimin Meng,Zhishu Gong,Yunhui Zong,Lei Huang,Man Lu,Jirong Tang,Yafen Li,Xiaochen Zhai,Xiangling Wang,Sisi Ye,Dan Chen,Lei Yuan,Lin Qi,Yang Lin +22 more
TL;DR: Two anti-MUC1 CAR-T cell lines were constructed and it was shown that pSM3-CAR effectively caused tumor necrosis, providing new options for improvedCAR-T therapy in solid tumors.
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The Role of Chaperone-Mediated Autophagy in Huntingtin Degradation
TL;DR: Investigation of the regulatory role of chaperone-mediated autophagy components, heat shock protein cognate 70 (Hsc70) and lysosome-associated protein 2A (LAMP-2A) in degradation of Htt fragment 1-552aa confirms previous reports and suggests a novel strategy to target the degradation of mutant Htt.