L
Lina M. Obeid
Researcher at Stony Brook University
Publications - 301
Citations - 33238
Lina M. Obeid is an academic researcher from Stony Brook University. The author has contributed to research in topics: Ceramide & Sphingolipid. The author has an hindex of 95, co-authored 296 publications receiving 30641 citations. Previous affiliations of Lina M. Obeid include Sewanee: The University of the South & State University of New York System.
Papers
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Journal ArticleDOI
Principles of bioactive lipid signalling: lessons from sphingolipids
TL;DR: An understanding of the complex pathways of sphingolipid metabolism and the mechanisms that regulate lipid generation and lipid action is required to understand the mechanisms of cell growth, death, senescence, adhesion, migration, inflammation, angiogenesis and intracellular trafficking.
Journal ArticleDOI
Programmed cell death induced by ceramide
TL;DR: The effects of C2-ceramide on DNA fragmentation were prevented by the protein kinase C activator phorbol 12-myristate 13-acetate, which suggests the existence of two opposing intracellular pathways in the regulation of apoptosis.
Journal ArticleDOI
Sphingolipids and their metabolism in physiology and disease.
TL;DR: These results highlight critical roles for bioactive sphingolipids in most, if not all, major cell biological responses, including all major cell signalling pathways, and they link sphingoipid metabolism to key human diseases.
Journal ArticleDOI
The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind.
Yusuf A. Hannun,Lina M. Obeid +1 more
Book ChapterDOI
An overview of sphingolipid metabolism: from synthesis to breakdown.
TL;DR: This chapter will pay tribute to the complex regulation of simple sphingolipids, a class of lipids defined by their eighteen carbon amino-alcohol backbones that play significant roles in membrane biology and provide many bioactive metabolites that regulate cell function.