Lincoln V. Johnson

TL;DR: It is shown that factor H (HF1), the major inhibitor of the alternative complement pathway, accumulates within drusen and is synthesized by the retinal pigmented epithelium, implicating HF1 function in the pathogenetic mechanisms underlying AMD.

TL;DR: With the use of rhodamine 123, it is possible to detect alterations in mitochondrial distribution following transformation by Rous sarcoma virus and changes in the shape and organization of mitochondria induced by colchicine treatment.

TL;DR: An integrated ultrastructural, histochemical, molecular biological, and biochemical approach is described to identify specific molecular pathways associated with drusen biogenesis and invokes, for the first time, the potential for a direct role of cell- and immune-mediated processes in drusens biogenesis.

TL;DR: In this paper, a more complete profile of the molecular composition of drusen has emerged and their implications for the pathogenic events that give rise to age-related macular degeneration (AMD).

TL;DR: Permeant cationic fluorescent probes are shown to be selectively accumulated by the mitochondria of living cells and application of such potential-dependent probes in conjunction with fluorescence microscopy allows the monitoring of mitochondrial membrane potential in individual living cells.