L
Linda A. Bradley
Researcher at Centers for Disease Control and Prevention
Publications - 44
Citations - 5145
Linda A. Bradley is an academic researcher from Centers for Disease Control and Prevention. The author has contributed to research in topics: Population & Odds ratio. The author has an hindex of 25, co-authored 44 publications receiving 4910 citations. Previous affiliations of Linda A. Bradley include Office of Public Health Genomics & Brown University.
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Journal ArticleDOI
Prevalence and Penetrance of Germline BRCA1 and BRCA2 Mutations in a Population Series of 649 Women with Ovarian Cancer
Harvey A. Risch,John R. McLaughlin,David E. C. Cole,Barry P. Rosen,Linda A. Bradley,Elaine Kwan,Elaine Jack,Danny Vesprini,Graciela Kuperstein,John L.A. Abrahamson,Isabel Fan,Betty Y.L. Wong,Steven A. Narod +12 more
TL;DR: Risks of ovarian, breast, and stomach cancers and leukemias/lymphomas were increased nine-, five-, six- and threefold, respectively, among first-degree relatives of cases carrying BRCA1 mutations, compared with relatives of noncarriers, and risk of colorectal cancer was increased threefold for relatives of Cases carrying B RCA2 mutations.
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The continuum of translation research in genomic medicine: how can we accelerate the appropriate integration of human genome discoveries into health care and disease prevention?
Muin J. Khoury,Marta Gwinn,Paula W. Yoon,Nicole F. Dowling,Cynthia A. Moore,Linda A. Bradley +5 more
TL;DR: A framework for the continuum of multidisciplinary translation research that builds on previous characterization efforts in genomics and other areas in health care and prevention is presented and the types of translation research can overlap and provide feedback loops to allow integration of new knowledge.
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Population BRCA1 and BRCA2 Mutation Frequencies and Cancer Penetrances: A Kin–Cohort Study in Ontario, Canada
Harvey A. Risch,John R. McLaughlin,David E. C. Cole,Barry P. Rosen,Linda A. Bradley,Isabel Fan,James Tang,Song Li,Shiyu Zhang,Patricia Shaw,Steven A. Narod +10 more
TL;DR: BRCA1 and BRCA2 mutations may be more frequent in general populations than previously thought and may be associated with various types of cancers.
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The Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Initiative: methods of the EGAPP Working Group.
Steven M. Teutsch,Linda A. Bradley,Glenn E. Palomaki,James E. Haddow,Margaret Piper,Ned Calonge,W. David Dotson,Michael P. Douglas,Alfred O. Berg +8 more
TL;DR: The EGAPP processes are described and the specific methods and approaches used by the EWG are described, which include an independent, non-federal Working Group, a multidisciplinary expert panel, and a systematic review of evidence.
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Reporting, Appraising, and Integrating Data on Genotype Prevalence and Gene-Disease Associations
Julian Little,Linda A. Bradley,Molly S. Bray,Mindy Clyne,Janice S. Dorman,Darrell L Ellsworth,James W. Hanson,Muin J. Khoury,Joseph Lau,Thomas R. O'Brien,Nat Rothman,Donna F. Stroup,Emanuela Taioli,Duncan C. Thomas,Harri Vainio,Sholom Wacholder,Clarice R. Weinberg +16 more
TL;DR: A checklist for reporting and appraising studies of genotype prevalence and studies of gene-disease associations was developed and focuses on selection of study subjects, analytic validity of genotyping, population stratification, and statistical issues.