L
Linda Chang
Researcher at University of Maryland, Baltimore
Publications - 276
Citations - 23444
Linda Chang is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Working memory & Methamphetamine. The author has an hindex of 81, co-authored 267 publications receiving 20430 citations. Previous affiliations of Linda Chang include Brookhaven National Laboratory & University of Hawaii at Manoa.
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Journal ArticleDOI
Family income, parental education and brain structure in children and adolescents
Kimberly G. Noble,Suzanne M. Houston,Natalie H. Brito,Hauke Bartsch,Eric Kan,Joshua M. Kuperman,Natacha Akshoomoff,David G. Amaral,Cinnamon S. Bloss,Ondrej Libiger,Nicholas J. Schork,Sarah S. Murray,B. J. Casey,Linda Chang,Thomas Ernst,Jean A. Frazier,Jeffrey R. Gruen,David N. Kennedy,Peter C.M. van Zijl,Stewart H. Mostofsky,Walter E. Kaufmann,Tal Kenet,Anders M. Dale,Terry L. Jernigan,Elizabeth R. Sowell +24 more
TL;DR: Investigation of relationships between socioeconomic factors and brain morphometry among a cohort of typically developing individuals suggests that income relates most strongly to brain structure among the most disadvantaged children.
Journal ArticleDOI
Association of Dopamine Transporter Reduction With Psychomotor Impairment in Methamphetamine Abusers
Nora D. Volkow,Linda Chang,Gene-Jack Wang,Joanna S. Fowler,Maria Leonido-Yee,Dinko Franceschi,Mark J. Sedler,S. John Gatley,Robert Hitzemann,Yu-Shin Ding,Jean Logan,Christopher Wong,Eric N. Miller +12 more
TL;DR: Evidence is provided that methamphetamine at dose levels taken by human abusers of the drug leads to dopamine transporter reduction that is associated with motor and cognitive impairment and the urgency of alerting clinicians and the public of the long-term changes that methamphetamine can induce in the human brain.
Journal ArticleDOI
Low Level of Brain Dopamine D2 Receptors in Methamphetamine Abusers: Association With Metabolism in the Orbitofrontal Cortex
Nora D. Volkow,Linda Chang,Gene-Jack Wang,Joanna S. Fowler,Y.-S. Ding,Mark J. Sedler,Jean Logan,Dinko Franceschi,John Gatley,Robert Hitzemann,Andrew N. Gifford,Christopher Wong,Naomi Pappas +12 more
TL;DR: The association between level of dopamine D2 receptors and metabolism in the orbit ofrontal cortex in methamphetamine abusers suggests that D2 receptor-mediated dysregulation of the orbitofrontal cortex could underlie a common mechanism for loss of control and compulsive drug intake in drug-addicted subjects.
Journal ArticleDOI
Loss of Dopamine Transporters in Methamphetamine Abusers Recovers with Protracted Abstinence
Nora D. Volkow,Linda Chang,Gene-Jack Wang,Joanna S. Fowler,Dinko Franceschi,Mark J. Sedler,Samuel J. Gatley,Eric N. Miller,Robert Hitzemann,Yu-Shin Ding,Jean Logan +10 more
TL;DR: It is suggested that protracted abstinence may reverse some of methamphetamine-induced alterations in brain DA terminals, and neuropsychological tests did not improve to the same extent as during short abstinence, which suggests that the increase of the DA transporters was not sufficient for complete function recovery.
Journal ArticleDOI
Reduction of beta-amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease.
R. Motter,Carmen Vigo-Pelfrey,Dora Kholodenko,Robin Barbour,Kelly Johnson-Wood,Doug R. Galasko,Linda Chang,Bruce L. Miller,C. Clark,Robert C. Green,D. Olson,P. Southwick,R. Wolfert,B. Munroe,Ivan Lieberburg,Peter Seubert,Dale Schenk +16 more
TL;DR: It is interesting that CSF Aβ42 levels were found to be significantly lower in AD patients relative to controls, whereas total Aβ levels were not, and neither A β42 nor τ levels were apparently influenced by the ApoE genotype.