L
Linda M. Sanderson
Researcher at Wageningen University and Research Centre
Publications - 8
Citations - 598
Linda M. Sanderson is an academic researcher from Wageningen University and Research Centre. The author has contributed to research in topics: Peroxisome proliferator-activated receptor & Regulation of gene expression. The author has an hindex of 5, co-authored 8 publications receiving 550 citations.
Papers
More filters
Journal ArticleDOI
Comprehensive analysis of PPARalpha-dependent regulation of hepatic lipid metabolism by expression profiling.
Maryam Rakhshandehroo,Linda M. Sanderson,Merja Matilainen,Rinke Stienstra,Carsten Carlberg,Philip J. de Groot,Michael Müller,Sander Kersten +7 more
TL;DR: In this paper, the power of transcriptional profiling to uncover novel PPARα-regulated genes and pathways in liver was illustrated, using an in silico screening approach, one or more PPAR response elements were identified in each of these genes.
Journal ArticleDOI
Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) but not PPARα serves as a plasma free fatty acid sensor in liver.
Linda M. Sanderson,Tatjana Degenhardt,Arjen Koppen,Eric Kalkhoven,Béatrice Desvergne,Michael Müller,Sander Kersten +6 more
TL;DR: In this article, the authors investigated the similarities in gene induction between Wy14643 and fasting and showed that upregulation of gene expression by PPARbeta/delta is sensitive to plasma free fatty acid (FFA) levels.
Journal ArticleDOI
Effect of synthetic dietary triglycerides: a novel research paradigm for nutrigenomics.
Linda M. Sanderson,Philip J. de Groot,Guido J. E. J. Hooiveld,Arjen Koppen,Eric Kalkhoven,Michael Müller,Sander Kersten +6 more
TL;DR: The effects of dietary unsaturated fatty acids on hepatic gene expression are almost entirely mediated by PPARα and mimic those of synthetic PPAR α agonists in terms of regulation of target genes and molecular mechanism.
Journal ArticleDOI
Transcriptional profiling reveals divergent roles of PPARalpha and PPARbeta/delta in regulation of gene expression in mouse liver.
TL;DR: The analysis of whole genome transcriptional profiling and analysis of plasma and liver metabolites indicates that PPARbeta/delta governs glucose utilization and lipoprotein metabolism and has an important anti-inflammatory role in liver.
ResearchArticle Comprehensive Analysis of PPARα-Dependent Regulation of Hepatic Lipid Metabolism by Expression Profiling
Maryam Rakhshandehroo,Linda M. Sanderson,Merja Matilainen,Rinke Stienstra,Carsten Carlberg,Philip J. de Groot,Michael M,Sander Kersten +7 more
TL;DR: In wild-type mice fed a high fat diet, the decrease in hepatic lipids following treatment with the PPAR α agonist Wy14643 was paralleled by significant up-regulation of Pnpla2, Lipe, and Mgll, suggesting that induction of triglyceride hydrolysis may contribute to the anti-steatotic role of PPARα.