L
Linda M. Wakim
Researcher at University of Melbourne
Publications - 54
Citations - 6100
Linda M. Wakim is an academic researcher from University of Melbourne. The author has contributed to research in topics: Cytotoxic T cell & Antigen. The author has an hindex of 25, co-authored 46 publications receiving 4931 citations. Previous affiliations of Linda M. Wakim include Howard Hughes Medical Institute & Walter and Eliza Hall Institute of Medical Research.
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Journal ArticleDOI
Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus
Thomas Gebhardt,Linda M. Wakim,Liv Eidsmo,Patrick C. Reading,William R. Heath,Francis R. Carbone +5 more
TL;DR: A unique memory T cell subset present after acute infection with herpes simplex virus that remained resident in the skin and in latently infected sensory ganglia is described, representing an example of tissue-resident memory T cells that can provide protective immunity at points of pathogen entry.
Journal ArticleDOI
Cross-presentation of viral and self antigens by skin-derived CD103 + dendritic cells
Sammy Bedoui,Paul G. Whitney,Jason Waithman,Jason Waithman,Liv Eidsmo,Linda M. Wakim,Irina Caminschi,Rhys S. Allan,Magdalena Wojtasiak,Ken Shortman,Francis R. Carbone,Andrew G. Brooks,William R. Heath,William R. Heath +13 more
TL;DR: It is shown that CD103+ DCs were the migratory subset most efficient at processing viral antigens into the major histocompatibility complex class I pathway, potentially through cross-presentation.
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Epidermal Viral Immunity Induced by CD8α+ Dendritic Cells But Not by Langerhans Cells
Rhys S. Allan,Caleb Smith,Gabrielle T. Belz,Allison L. van Lint,Linda M. Wakim,William R. Heath,Francis R. Carbone +6 more
TL;DR: It is shown here that infection of murine epidermis by herpes simplex virus did not result in the priming of virus-specific cytotoxic T lymphocytes by Langerhans cells, rather, thePriming response required a distinct CD8α+ dendritic cell subset.
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Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence
TL;DR: For example, resident memory T cells (Trm) as mentioned in this paper were found to persist in the brain after removal of a virus from the tissue and after adoptive transfer into the bloodstream of antigen-challenged recipients.
Journal ArticleDOI
Dendritic cell-induced memory T cell activation in nonlymphoid tissues.
Linda M. Wakim,Jason Waithman,Jason Waithman,Jason Waithman,Nico van Rooijen,Nico van Rooijen,Nico van Rooijen,William R. Heath,William R. Heath,William R. Heath,Francis R. Carbone,Francis R. Carbone,Francis R. Carbone +12 more
TL;DR: Results revealed that memory CD8+ T cell responses can be initiated within peripheral tissues through a tripartite interaction that includes CD4+ T cells and recruited dendritic cells, lending evidence for the existence of a sophisticated T cell response mechanism in extra-lymphoid tissues that can act to control localized infection.