Linda Zhang

TL;DR: This work developed a chemical-assisted sequencing approach that selectively converts internal m7G sites into abasic sites, inducing misincorporation at these sites during reverse transcription and enabled transcriptome-wide mapping of m7g in human tRNA and mRNA, revealing distribution features of the internal m 7G methylome in human cells.

TL;DR: Deletion of Mettl14 impairs interleukin-7 (IL-7)-induced pro-B cell proliferation and the large-pre-B-to-small- pre-B transition and causes dramatic abnormalities in gene expression programs important for B cell development in mice.

TL;DR: A new mouse model of spontaneous colitis based on perturbation of RNA methylation in T cells is reported, which represents a new tool for elucidating pathogenic pathways, studying the contribution of intestinal microbiome and preclinical testing of therapeutic agents for inflammatory bowel disease.

TL;DR: This study reveals an unrecognized function of ERK in regulating m6A methylation, found that ERK phosphorylates METTL3 at S43/S50/S525 and WTAP at S306/S341, followed by deubiquitination by USP5, resulting in stabilization of the m 6A methyltransferase complex.

TL;DR: It is concluded that m6A methylation-mediated SOCS1 induction is required to maintain the negative feedback control of macrophage activation in response to bacterial infection.