L
Ling Zhang
Researcher at Peking Union Medical College
Publications - 34
Citations - 1943
Ling Zhang is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 13, co-authored 24 publications receiving 1339 citations.
Papers
More filters
Journal ArticleDOI
From SARS to MERS, Thrusting Coronaviruses into the Spotlight
Zhiqi Song,Yanfeng Xu,Linlin Bao,Ling Zhang,Pin Yu,Yajin Qu,Hua Zhu,Wenjie Zhao,Yunlin Han,Chuan Qin +9 more
TL;DR: The research still needed to fully elucidate the pathogenic mechanism of these viruses, to construct reproducible animal models, and ultimately develop countermeasures to conquer not only SARS-CoV and MERS-coV, but also these emerging coronaviral diseases are outlined.
Journal ArticleDOI
Altered Gut Microbiota in a Mouse Model of Alzheimer’s Disease
Ling Zhang,Ying Wang,Xia Xiayu,Changhua Shi,Wei Chen,Nan Song,Xinjing Fu,Rui Zhou,Yanfeng Xu,Lan Huang,Hua Zhu,Yunlin Han,Chuan Qin +12 more
TL;DR: It is shown that AD pathology might not only affect brain function directly, but also exacerbate cognitive deficits through reducing the level of SCFAs via alterations of gut microbiota induced by intestinal amyloid deposition, suggesting a novel route for therapeutic intervention in AD.
Journal ArticleDOI
Tubastatin A/ACY-1215 improves cognition in Alzheimer's disease transgenic mice.
Ling Zhang,Cui Liu,Jie Wu,Jing-jing Tao,Xiaolong Sui,Zhi-Gang Yao,Yanfeng Xu,Lan Huang,Hua Zhu,Shu-li Sheng,Chuan Qin +10 more
TL;DR: Preclinical results support the detrimental role of HDAC6 in AD, and offer prospective approaches for using tubastatin A/ACY-1215 as potential therapeutic strategy for AD.
Journal ArticleDOI
SARS-CoV-2 crosses the blood-brain barrier accompanied with basement membrane disruption without tight junctions alteration.
Ling Zhang,Li Zhou,Linlin Bao,Jiangning Liu,Hua Zhu,Qi Lv,Ruixue Liu,Wei Chen,Wei Tong,Qiang Wei,Yanfeng Xu,Wei Deng,Hong Gao,Jing Xue,Zhiqi Song,Pin Yu,Yunlin Han,Yu Zhang,Xiuping Sun,Xuan Yu,Chuan Qin +20 more
TL;DR: In this paper, SARS-CoV-2 was found to cross the BBB in a transcellular pathway accompanied with basement membrane disrupted without obvious alteration of tight junctions (TJs).
Journal ArticleDOI
The role of HDAC6 in Alzheimer's disease.
TL;DR: Light is shed on whether HDAC6 overexpression is associated with AD etiopathogenesis or whether it rescues AD-associated neurodegeneration compensatorily, and new evidence showing thatHDAC6 may be a therapeutic target for AD is discussed.