L
Lionel Larue
Researcher at Université Paris-Saclay
Publications - 205
Citations - 14951
Lionel Larue is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: Melanoma & Microphthalmia-associated transcription factor. The author has an hindex of 58, co-authored 193 publications receiving 13673 citations. Previous affiliations of Lionel Larue include Curie Institute & PSL Research University.
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Journal ArticleDOI
Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways.
Lionel Larue,Alfonso Bellacosa +1 more
TL;DR: The role of PI3K/AKT pathways in EMT during development and cancer with a focus on E-cadherin regulation is discussed, along with a discussion of the therapeutic implications of modulating EMT in order to achieve cancer control.
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E-cadherin null mutant embryos fail to form a trophectoderm epithelium
TL;DR: The pivotal role of E-cadherin in one of the most basic morphogenetic events in the development of multicellular organisms, the biogenesis of an epithelium, is demonstrated.
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Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair.
Salvatore Cortellino,Jinfei Xu,Mara Sannai,Robert Moore,Elena Caretti,Antonio Cigliano,Madeleine Le Coz,Karthik Devarajan,Andy Wessels,Dianne Robert Soprano,Lara K. Abramowitz,Marisa S. Bartolomei,Florian Rambow,Florian Rambow,Maria Rosaria Bassi,Tiziana Bruno,Maurizio Fanciulli,Catherine Renner,Andres J. Klein-Szanto,Yoshihiro Matsumoto,Dominique Kobi,Irwin Davidson,Christophe Alberti,Christophe Alberti,Lionel Larue,Lionel Larue,Alfonso Bellacosa +26 more
TL;DR: It is shown that either knockout or catalytic inactivation of the DNA repair enzyme thymine DNA glycosylase (TDG) leads to embryonic lethality in mice, and a dual role for TDG in promoting proper epigenetic states during development is highlighted, suggesting a two-step mechanism for DNA demethylation in mammals.
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Lack of beta-catenin affects mouse development at gastrulation
TL;DR: It is demonstrated that, although beta-catenin is expressed rather ubiquitously, it is specifically required in the ectodermal cell layer, as it binds to the cytoplasmic domain of E-cadherin and to alpha-Catenin.
Journal Article
The Protein Kinase Akt Induces Epithelial Mesenchymal Transition and Promotes Enhanced Motility and Invasiveness of Squamous Cell Carcinoma Lines
Sylvia Grille,Alfonso Bellacosa,John J. Upson,Andres J. Klein-Szanto,Frans van Roy,Whaseon Lee-Kwon,Mark Donowitz,Philip N. Tsichlis,Lionel Larue +8 more
TL;DR: Squamous cell carcinoma lines engineered to express constitutively active Akt underwent EMT, characterized by down-regulation of the epithelial markers desmoplakin, E-cadherin, and beta-catenin and up- regulation of the mesenchymal marker vimentin.