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Liqin Wang

Bio: Liqin Wang is an academic researcher from Yunnan Normal University. The author has contributed to research in topics: Caesalpinia & Chalcone. The author has an hindex of 9, co-authored 29 publications receiving 260 citations.
Topics: Caesalpinia, Chalcone, Erythrina, Chemistry, Viburnum

Papers
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Journal ArticleDOI
TL;DR: A phytochemical study of the whole plant of Bulbophyllum odoratissimum (J.E. Smith) Lindl (Orchidaceae) and cytotoxicity measurement of its isolated compounds have been carried out and all compounds, except for 9, have not been reported in this plant before.

66 citations

Journal ArticleDOI
Ye-Gao Chen1, Yu-Peng Li1, Chen Qing, Yanli Zhang, Liqin Wang1, Ying Liu1 
TL;DR: A new compound, 1,4,5-trihydroxy-7-methoxy-9H-fluoren-9-one, has been isolated together with two known fluorenones, dendroflorin and denchrysan A, from the whole plant of Dendrobium chrysotoxum, a plant used as a health-food.

33 citations

Journal ArticleDOI
Jiang-Tao Li1, Ben-Lin Yin1, Ying Liu1, Liqin Wang1, Ye-Gao Chen1 
TL;DR: Wang et al. as mentioned in this paper reported that Dendrobium species (Orchidaceae) is used in traditional Chinese medicine as a tonic to nourish the stomach, promote the production of body fluid, and reduce fever.
Abstract: The stems of several Dendrobium species (Orchidaceae) are used in traditional Chinese medicine as a tonic to nourish the stomach, promote the production of body fluid, and reduce fever [1]. The products prepared from the dried stems of Dendrobium plants are also used as precious health foods and nutrients [2]. Earlier work on the genus led to the isolation of a series of compounds such as alkaloids, fluorenones, sesquiterpenoids, bibenzyls, and phenanthrenes with antioxidant, antitumor, antimutagenic, and other activities [3–6]. D. longicornu Lindl is distributed in Nepal, Sikkim, Bhutan, India, Vietnam, and the southwestern part of China [7]. Previously, there have been no reports on its chemical constituents. In the course of our search for new bioactive natural products from medicinal plants in Yunnan of China, we investigated the plant. D. longicornu was collected from Lianghe County of Yunnan Province, China in September, 2004. The air-dried whole plants (3.4 kg) were chopped and extracted with 95% EtOH five times (each 20 L) at room temperature. The EtOH extract (115 g) was diluted with H2O (1 L) and then extracted with petroleum ether, EtOAc, and n-BuOH (each 0.5 L, five times) successively. Evaporation of the respective solvents gave the petroleum ether (30 g), EtOAc (26 g), and n-BuOH (52 g) extracts. The EtOAc extract (26 g) was applied to a silica gel column (200–300 mesh, 100 cm × 10 cm), eluting with petroleum ether containing increasing amounts of acetone to obtain six fractions monitored by TLC tests. Spots on the plate were observed under UV light and visualized by spraying with 15% H2SO4 in ethanol followed by heating. Fraction 1 (2 g) was further purified on column chromatography (silica gel, 200–300 mesh, 60 cm × 4 cm, petroleum ether–acetone 30:1) to afford five subfractions. The second and third subfractions were isolated on preparative TLC (20 cm × 20 cm, petroleum ether–benzene 1:1) to afford 1 (40 mg) and 2 (35 mg), respectively. The fourth subfraction was purified by recrystallization from acetone to obtain 8 (100 mg); Fr. 2 (4.5 g) was separated on column chromatography (silica gel, 200–300 mesh, 60 cm × 5 cm, CHCl3–acetone 15:1) to yield five subfractions. The second subfraction was isolated on a Sephadex LH-20 column (120 cm × 3 cm, MeOH) to obtain 5 (15 mg). The third subfraction was purified on a preparative TLC plate (20 cm × 20 cm, petroleum ether– EtOAc 9:1) to afford 7 (8 mg). The fourth subfraction was separated on a preparative TLC plate (20 cm × 20 cm, CHCl3–acetone 15:1) to afford 6 (6 mg); Fr. 5 (9 g) was purified on column chromatography (silica gel, 200–300 mesh, 60 cm × 4 cm, CHCl3–acetone 10:1) to afford two subfractions. The second subfraction (3 g) was subjected to repeated column chromatography similarly, first on Sephadex LH-20 (MeOH), and then on preparative TLC (20 cm × 20 cm, petroleum ether– EtOAc 2:1, CHCl3–MeOH 15:1) to isolate 3 (11 mg) and 4 (20 mg).

19 citations

Journal ArticleDOI
TL;DR: New chalcone and dimeric chalcones with 1,4- P-benzoquinone residue,Combretum yunnanense, along with three known compounds, were isolated from the ethanolic extract of the stems and leaves of Combretum gaelicense, and their structures were determined by spectroscopic analysis.
Abstract: New chalcone and dimeric chalcones with 1,4-p-benzoquinone residue, combrequinone A (1), combrequinone B (2), and combrequinone C (3), along with three known compounds (4-6), were isolated from the ethanolic extract of the stems and leaves of Combretum yunnanense, and their structures were determined by spectroscopic analysis. Compounds 1-3 were evaluated for in vitro cytotoxicity against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7, and SW480. Compounds 1, 2, and 3 were found to be most potent against HL-60 acute leukemia cells, with IC(50) values of 4.63, 4.07, and 1.26 mu M, respectively.

18 citations


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TL;DR: The distribution of ka Kempferol in the plant kingdom and its pharmacological properties are reviewed and the pharmacokinetics and safety of kaempferol are analyzed to help understand the health benefits of kaEMPferol-containing plants and to develop this flavonoid as a possible agent for the prevention and treatment of some diseases.
Abstract: Epidemiological studies have revealed that a diet rich in plant-derived foods has a protective effect on human health. Identifying bioactive dietary constituents is an active area of scientific investigation that may lead to new drug discovery. Kaempferol (3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) is a flavonoid found in many edible plants (e.g. tea, broccoli, cabbage, kale, beans, endive, leek, tomato, strawberries and grapes) and in plants or botanical products commonly used in traditional medicine (e.g. Ginkgo biloba, Tilia spp, Equisetum spp, Moringa oleifera, Sophora japonica and propolis). Some epidemiological studies have found a positive association between the consumption of foods containing kaempferol and a reduced risk of developing several disorders such as cancer and cardiovascular diseases. Numerous preclinical studies have shown that kaempferol and some glycosides of kaempferol have a wide range of pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer, cardioprotective, neuroprotective, antidiabetic, anti-osteoporotic, estrogenic/antiestrogenic, anxiolytic, analgesic and antiallergic activities. In this article, the distribution of kaempferol in the plant kingdom and its pharmacological properties are reviewed. The pharmacokinetics (e.g. oral bioavailability, metabolism, plasma levels) and safety of kaempferol are also analyzed. This information may help understand the health benefits of kaempferol-containing plants and may contribute to develop this flavonoid as a possible agent for the prevention and treatment of some diseases.

987 citations

Journal ArticleDOI
TL;DR: Five new phenolic compounds, gramniphenols C-G (1-5), and eight known compounds (6-13) were isolated from the whole plant of Arundina gramnifolia, showing anti-tobacco mosaic virus activity and anti-HIV-1 activity.
Abstract: Five new phenolic compounds, gramniphenols C–G (1–5), and eight known compounds (6–13) were isolated from the whole plant of Arundina gramnifolia. Compounds 1, 4, and 5 showed anti-tobacco mosaic virus activity, with IC50 values of 20.8, 40.8, and 57.7 μM, respectively. Compounds 1–10 were also tested for their anti-HIV-1 activity; compounds 2, 3, and 6 displayed anti-HIV-1 activity with therapeutic index values above 100:1.

154 citations