L
Lisa Derosa
Researcher at Institut Gustave Roussy
Publications - 135
Citations - 8315
Lisa Derosa is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Renal cell carcinoma & Medicine. The author has an hindex of 29, co-authored 109 publications receiving 4667 citations. Previous affiliations of Lisa Derosa include French Institute of Health and Medical Research & University of Pisa.
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Journal ArticleDOI
Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors
Bertrand Routy,Bertrand Routy,Bertrand Routy,Lisa Derosa,Lisa Derosa,Lisa Derosa,Connie P.M. Duong,Connie P.M. Duong,Maryam Tidjani Alou,Maryam Tidjani Alou,Maryam Tidjani Alou,Romain Daillère,Romain Daillère,Romain Daillère,Aurélie Fluckiger,Aurélie Fluckiger,Meriem Messaoudene,Meriem Messaoudene,Conrad Rauber,Conrad Rauber,Conrad Rauber,Maria Paula Roberti,Maria Paula Roberti,Marine Fidelle,Marine Fidelle,Caroline Flament,Caroline Flament,Vichnou Poirier-Colame,Vichnou Poirier-Colame,Paule Opolon,Christophe Klein,Kristina Iribarren,Laura Mondragón,Nicolas Jacquelot,Nicolas Jacquelot,Nicolas Jacquelot,Bo Qu,Bo Qu,Bo Qu,Gladys Ferrere,Gladys Ferrere,Gladys Ferrere,Céline Clémenson,Céline Clémenson,Laura Mezquita,Jordi Remon Masip,C. Naltet,Solenn Brosseau,Coureche Kaderbhai,Corentin Richard,Hira Rizvi,Florence Levenez,Nathalie Galleron,Benoit Quinquis,Nicolas Pons,Bernhard Ryffel,Veronique Minard-Colin,Patrick Gonin,Jean-Charles Soria,Eric Deutsch,Eric Deutsch,Yohann Loriot,Yohann Loriot,François Ghiringhelli,Gérard Zalcman,François Goldwasser,B. Escudier,B. Escudier,Matthew D. Hellmann,Matthew D. Hellmann,Alexander M.M. Eggermont,Alexander M.M. Eggermont,Didier Raoult,Laurence Albiges,Laurence Albiges,Guido Kroemer,Laurence Zitvogel +76 more
TL;DR: It is found that primary resistance to ICIs can be attributed to abnormal gut microbiome composition, and Antibiotics inhibited the clinical benefit of ICIs in patients with advanced cancer.
Journal ArticleDOI
Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19.
Aymeric Silvin,Nicolas Chapuis,Garett Dunsmore,Anne-Gaëlle Goubet,Agathe Dubuisson,Lisa Derosa,Carole Almire,Clémence Hénon,Olivier Kosmider,Nathalie Droin,Philippe Rameau,Cyril Catelain,Alexia Alfaro,Charles Dussiau,Chloé Friedrich,Elise Sourdeau,Nathalie Marin,T.-A. Szwebel,Delphine Cantin,Luc Mouthon,Didier Borderie,Marc Deloger,Delphine Bredel,Severine Mouraud,Damien Drubay,Muriel Andrieu,Anne-Sophie Lhonneur,Véronique Saada,Annabelle Stoclin,Christophe Willekens,Fanny Pommeret,Frank Griscelli,Lai Guan Ng,Zheng Zhang,Pierre Bost,Pierre Bost,Ido Amit,Fabrice Barlesi,Aurélien Marabelle,Frédéric Pène,Bertrand Gachot,Fabrice Andre,Fabrice Andre,Laurence Zitvogel,Laurence Zitvogel,Laurence Zitvogel,Florent Ginhoux,Florent Ginhoux,Florent Ginhoux,Michaela Fontenay,Eric Solary,Eric Solary +51 more
TL;DR: It is shown that calprotectin plasma level and a routine flow cytometry assay detecting decreased frequencies of non-classical monocytes could discriminate patients who develop a severe COVID-19 form, suggesting a predictive value that deserves prospective evaluation.
Journal ArticleDOI
Negative association of antibiotics on clinical activity of immune checkpoint inhibitors in patients with advanced renal cell and non-small-cell lung cancer
Lisa Derosa,Lisa Derosa,Lisa Derosa,Matthew D. Hellmann,Matthew D. Hellmann,M. Spaziano,Darragh Halpenny,Marine Fidelle,Marine Fidelle,Marine Fidelle,Hira Rizvi,Niamh Long,Andrew J. Plodkowski,Kathryn C. Arbour,Jamie E. Chaft,Jamie E. Chaft,J.A. Rouche,Laurence Zitvogel,Gérard Zalcman,Laurence Albiges,Bernard Escudier,Bertrand Routy +21 more
TL;DR: ATB were associated with reduced clinical benefit from ICI in RCC and NSCLC and Modulatation of ATB-related dysbiosis and gut microbiota composition may be a strategy to improve clinical outcomes with ICI.
Journal ArticleDOI
The Detection of Androgen Receptor Splice Variant 7 in Plasma-derived Exosomal RNA Strongly Predicts Resistance to Hormonal Therapy in Metastatic Prostate Cancer Patients
Marzia Del Re,Elisa Biasco,Stefania Crucitta,Lisa Derosa,Eleonora Rofi,Cinzia Orlandini,Mario Miccoli,Luca Galli,Alfredo Falcone,G. Jenster,Ron H.N. van Schaik,Romano Danesi +11 more
TL;DR: This study demonstrates that plasma-derived exosomal RNA is a reliable source of AR-V7 that can be detected sensitively by ddPCR assay and shows that resistance to hormonal therapy may be predicted by AR-v7, making it a clinically relevant biomarker.
Journal ArticleDOI
Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage.
Aurélie Fluckiger,Aurélie Fluckiger,Romain Daillère,Romain Daillère,Mohamed Sassi,Barbara S. Sixt,Peng Liu,Friedemann Loos,Corentin Richard,Catherine Rabu,Maryam Tidjani Alou,Maryam Tidjani Alou,Maryam Tidjani Alou,Anne Gaëlle Goubet,Anne Gaëlle Goubet,Fabien Lemaitre,Gladys Ferrere,Gladys Ferrere,Lisa Derosa,Lisa Derosa,Lisa Derosa,Connie P.M. Duong,Connie P.M. Duong,Meriem Messaoudene,Andréanne Gagné,Philippe Joubert,Luisa De Sordi,Luisa De Sordi,Laurent Debarbieux,Sylvain Simon,Clara-Maria Scarlata,Maha Ayyoub,Belinda Palermo,Francesco Facciolo,Romain Boidot,Richard J. Wheeler,Ivo G. Boneca,Zsofia Sztupinszki,Krisztián Papp,István Csabai,Edoardo Pasolli,Nicola Segata,Carlos López-Otín,Zoltan Szallasi,Fabrice Andre,Valerio Iebba,Valerio Iebba,Valerio Iebba,Valentin Quiniou,David Klatzmann,Jacques Bou-Khalil,Saber Khelaifia,Didier Raoult,Laurence Albiges,B. Escudier,B. Escudier,Alexander M.M. Eggermont,Fathia Mami-Chouaib,Paola Nisticò,François Ghiringhelli,Bertrand Routy,Nathalie Labarrière,Vincent Cattoir,Guido Kroemer,Laurence Zitvogel +64 more
TL;DR: In renal and lung cancer patients, the presence of the enterococcal prophage in stools and expression of a TMP–cross-reactive antigen by tumors correlated with long-term benefit of PD-1 blockade therapy.