L
Lisa F. Dawson
Researcher at University of London
Publications - 32
Citations - 2269
Lisa F. Dawson is an academic researcher from University of London. The author has contributed to research in topics: Clostridium difficile & Gene. The author has an hindex of 17, co-authored 31 publications receiving 2013 citations. Previous affiliations of Lisa F. Dawson include National Institute for Medical Research.
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Journal ArticleDOI
Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium
Richard A. Stabler,Miao-Xia He,Lisa F. Dawson,Melissa J. Martin,Esmeralda Valiente,Craig Corton,Trevor D. Lawley,Mohammed Sebaihia,Michael A. Quail,Graham Rose,Dale N. Gerding,Maryse Gibert,Michel R. Popoff,Julian Parkhill,Gordon Dougan,Brendan W. Wren +15 more
TL;DR: This study provides genetic markers for the identification of 027 strains and offers a unique opportunity to explain the recent emergence of a hypervirulent bacterium.
Journal ArticleDOI
Evolutionary dynamics of Clostridium difficile over short and long time scales
Miao He,Mohammed Sebaihia,Trevor D. Lawley,Richard A. Stabler,Lisa F. Dawson,Melissa J. Martin,Kathryn E. Holt,Helena M. B. Seth-Smith,Michael A. Quail,Richard Rance,Karen Brooks,Carol Churcher,David Harris,Stephen D. Bentley,Christine Burrows,Louise Clark,Craig Corton,Vicky Murray,Graham Rose,Scott Thurston,Andries J. van Tonder,Danielle Walker,Brendan W. Wren,Gordon Dougan,Julian Parkhill +24 more
TL;DR: Phylogenetic analysis demonstrates C. difficile is a genetically diverse species, which has evolved within the last 1.1–85 million years, and the disease-causing isolates have arisen from multiple lineages, suggesting that virulence evolved independently in the highly epidemic lineages.
Journal ArticleDOI
The Clostridium difficile spo0A Gene Is a Persistence and Transmission Factor
Laura J. Deakin,Simon Clare,Robert P. Fagan,Lisa F. Dawson,Derek Pickard,Michael R. West,Brendan W. Wren,Neil F. Fairweather,Gordon Dougan,Trevor D. Lawley +9 more
TL;DR: The C. difficile spo0A protein plays a key role in persistent infection, including recurrence and host-to-host transmission in mice, and is demonstrated to cause intestinal disease but are unable to persist within and effectively transmit between mice.
Journal ArticleDOI
Characterisation of Clostridium difficile biofilm formation, a role for Spo0A.
Lisa F. Dawson,Esmeralda Valiente,Alexandra Faulds-Pain,Elizabeth H. Donahue,Brendan W. Wren +4 more
TL;DR: It is demonstrated that C. difficile aggregates and forms biofilms in vitro on abiotic surfaces by an extracellular polymeric substance (EPS), which may have significant implications for infection, treatment and relapse.
Journal ArticleDOI
Macro and micro diversity of Clostridium difficile isolates from diverse sources and geographical locations.
Richard A. Stabler,Lisa F. Dawson,Esmeralda Valiente,M. D. Cairns,M. D. Cairns,M. D. Cairns,Melissa J. Martin,Elizabeth H. Donahue,Thomas V. Riley,J. Glenn Songer,Ed J. Kuijper,Kate E. Dingle,Brendan W. Wren +12 more
TL;DR: The evolutionary origin of dominant C. difficile lineages is defined and it is demonstrated that C. Difficile is continuing to evolve in concert with human activity.