L
Lisa M. H. Helms
Researcher at University of Alberta
Publications - 10
Citations - 873
Lisa M. H. Helms is an academic researcher from University of Alberta. The author has contributed to research in topics: Calcineurin & Proteases. The author has an hindex of 9, co-authored 10 publications receiving 847 citations.
Papers
More filters
Journal ArticleDOI
The temporal profile of calcineurin inhibition by cyclosporine in vivo.
TL;DR: CsA induces partial CN inhibition that varies directly with the blood and tissue levels, and may be greater in some tissues due to higher drug accumulation, relevant to nephrotoxicity.
Journal ArticleDOI
Telomere Shortening in Kidneys with Age
Anette Melk,Anette Melk,Vido Ramassar,Lisa M. H. Helms,Ronald B. Moore,David C. Rayner,Kim Solez,Philip F. Halloran +7 more
TL;DR: It is indicated that telomeres shorten in an age-dependent manner in the kidney, either due to developmental factors or aging, particularly in renal cortex.
Journal ArticleDOI
Serine-protease inhibition during islet isolation increases islet yield from human pancreases with prolonged ischemia.
Lakey,Lisa M. H. Helms,Tatsuya Kin,Gregory S. Korbutt,Ray V. Rajotte,A. M. J. Shapiro,Garth L. Warnock +6 more
TL;DR: Inhibition of intrinsic protease activity within pancreases after prolonged cold storage improves isolation of viable islets.
Journal ArticleDOI
Interferon-γ Acts Directly on Rejecting Renal Allografts to Prevent Graft Necrosis
Philip F. Halloran,Marjan Afrouzian,Vido Ramassar,Joan Urmson,Lin Fu Zhu,Lisa M. H. Helms,Kim Solez,Norman M. Kneteman +7 more
TL;DR: IFN-γ acting on IFn-γ receptors in allografts promotes infiltration and MHC induction but prevents early thrombosis, congestion, and necrosis.
Journal ArticleDOI
Tissue Distribution of Calcineurin and its Sensitivity to Inhibition by Cyclosporine
Lina Kung,Thomas D. Batiuk,Silvia Palomo-Pinon,J. Noujaim,Lisa M. H. Helms,Philip F. Halloran +5 more
TL;DR: Each cyclosporine dose produces rapid and widespread inhibition of calcineurin in tissues, with differences in total susceptibility of each tissue.