Lisa-Maria Needham

TL;DR: A G4-specific fluorescent probe (SiR-PyPDS) has been developed that enables single-molecule and real-time detection of individual G4 structures in living cells without perturbing G4 formation and dynamics.

TL;DR: It is concluded that poly(ADP-ribose) plays a central chemical role in both pathological and physiological extracellular matrix calcification, suggesting a therapeutic route for the treatment of vascular calcifications.

TL;DR: These results show that high control over h-BN growth and treatment can produce a narrow distribution of emitter type and that surface interactions heavily influence the photodynamics, and highlight the utility of spectrally resolved wide-field microscopy in the study of optically active excitations in atomically thin two-dimensional materials.

TL;DR: A two-step rational design method for the discovery of oligomer-specific antibodies that enables the accurate detection and quantification of Aβ oligomers in vitro, and in Caenorhabditis elegans and mouse hippocampal tissues.

TL;DR: Thioflavin X, (ThX), a next-generation fluorescent probe which displays superior properties; including a 5-fold increase in brightness and 7-fold increased in binding affinity to amyloidogenic proteins, is designed.