L
Liviu-Gabriel Bodea
Researcher at University of Queensland
Publications - 24
Citations - 2497
Liviu-Gabriel Bodea is an academic researcher from University of Queensland. The author has contributed to research in topics: Tauopathy & Medicine. The author has an hindex of 11, co-authored 18 publications receiving 1909 citations. Previous affiliations of Liviu-Gabriel Bodea include University of Bucharest & University Hospital Bonn.
Papers
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Journal ArticleDOI
Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease
Bin Zhang,Chris Gaiteri,Liviu-Gabriel Bodea,Zhi Wang,Joshua J McElwee,Alexei A. Podtelezhnikov,Chunsheng Zhang,Tao Xie,Linh M. Tran,Radu Dobrin,Eugene M. Fluder,Bruce E. Clurman,Stacey Melquist,Manikandan Narayanan,Christine Suver,Hardik Shah,Milind Mahajan,Tammy Gillis,Jayalakshmi S. Mysore,Marcy E. MacDonald,John Lamb,David A. Bennett,Cliona Molony,David J. Stone,Vilmundur Gudnason,Amanda J. Myers,Eric E. Schadt,Harald Neumann,Jun Zhu,Valur Emilsson +29 more
TL;DR: The causal network structure is a useful predictor of response to gene perturbations and presents a framework to test models of disease mechanisms underlying LOAD.
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Amyloid-β and tau complexity - towards improved biomarkers and targeted therapies
Juan Carlos Polanco,Chuanzhou Li,Liviu-Gabriel Bodea,Ramón Martínez-Mármol,Frederic A. Meunier,Jürgen Götz +5 more
TL;DR: The complexity of Aβ biogenesis, trafficking, post-translational modifications and aggregation states are discussed, as well as the concept of protein 'strains', and how this knowledge can facilitate the development of early disease biomarkers for stratifying patients and validating new therapies are discussed.
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Rodent models for Alzheimer disease
TL;DR: This Review critically evaluates the genetic and non-genetic strategies used in AD modelling, discussing their strengths and limitations, as well as new opportunities for the development of better models for the disease.
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Neurodegeneration by Activation of the Microglial Complement–Phagosome Pathway
Liviu-Gabriel Bodea,Yiner Wang,Bettina Linnartz-Gerlach,Jens Kopatz,Lasse Sinkkonen,Ruth E. Musgrove,Tony Kaoma,Arnaud Muller,Laurent Vallar,Donato A. Di Monte,Rudi Balling,Harald Neumann +11 more
TL;DR: It is demonstrated in vivo that repeated systemic challenge of mice over four consecutive days with bacterial LPS maintained an elevated microglial inflammatory phenotype and induced loss of dopaminergic neurons in the substantia nigra, confirming the involvement of the complement system in neurodegeneration.
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Tau physiology and pathomechanisms in frontotemporal lobar degeneration
TL;DR: Different aspects of pathological tau phosphorylation, the protein's genomic and domain organization as well as its spreading in disease, together with MAPT‐associated mutations and their respective models are presented, providing a mechanistic explanation for the observations made in FTLD‐tau cases.