Lixin Zheng

TL;DR: It is shown that mTOR signalling in rat kidney cells is inhibited during initiation of autophagy, but reactivated by prolonged starvation, and this generates proto-lysosomal tubules and vesicles that extrude from autolysosomes and ultimately mature into functional lysosomes, thereby restoring the full complement of lysosity in the cell.

TL;DR: It is shown that Treg cells induced apoptosis of effector CD4+ T cells in vitro and in vivo in a mouse model of inflammatory bowel disease and cytokine deprivation–induced apoptosis is a prominent mechanism by which T Reg cells inhibit effector T cell responses.

TL;DR: It is shown that tumour necrosis factor (TNF) can mediate mature T-cell receptor-induced apoptosis through the p75 TNF receptor and suggest that autoregulatory apoptosis of the mature T cells can occur by two distinct molecular mechanisms.

TL;DR: Immunological, cellular, and molecular evidence indicates that throughout the life of a T cell, apoptosis may be evoked in excessive, harmful, or useless clonotypes to preserve a healthy and balanced immune system.

TL;DR: A conserved domain in the extracellular region of the 60- and 80-kilodalton tumor necrosis factor receptors was identified that mediates specific ligand-independent assembly of receptor trimers.