L
Liying Zhang
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 4
Citations - 1385
Liying Zhang is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Androgen & Prostate cancer. The author has an hindex of 4, co-authored 4 publications receiving 1333 citations.
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Journal ArticleDOI
Gene Expression Analysis of Human Prostate Carcinoma during Hormonal Therapy Identifies Androgen-Responsive Genes and Mechanisms of Therapy Resistance
Jeff Holzbeierlein,Priti Lal,Eva Latulippe,Alex Smith,Jaya M. Satagopan,Liying Zhang,Charles J. Ryan,Steve Smith,Howard I. Scher,Howard I. Scher,Peter T. Scardino,Victor E. Reuter,William L. Gerald +12 more
TL;DR: A genome-wide expression analysis of human prostate cancer during androgen ablation therapy to identify genes regulated by androgen and genes differentially expressed after the development of resistance suggested that resistant tumors have increased sensitivity to and endogenous synthesis of androgenic hormones.
Journal ArticleDOI
An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen
Ashley S. Doane,Michael A. Danso,Priti Lal,M. Donaton,Liying Zhang,Clifford A. Hudis,William L. Gerald +6 more
TL;DR: This subset of BCs, characterized by a hormonally regulated transcriptional program and response to androgen, suggests the potential for therapeutic strategies targeting the androgen signaling pathway.
Journal ArticleDOI
NF-κB Regulates Androgen Receptor Expression and Prostate Cancer Growth
Liying Zhang,Saleh Altuwaijri,Fangming Deng,Lishi Chen,Priti Lal,U. Bhanot,Ruslan Korets,Sven Wenske,Hans Lilja,Chawnshang Chang,Howard I. Scher,William L. Gerald +11 more
TL;DR: It is found that NF-kappaB expression in prostate cancer cells significantly increased AR mRNA and protein levels, AR transactivation activity, serum prostate-specific antigen levels, and cell proliferation, and NF- kappaB inhibitors decrease AR expression levels, prostate- specific antigen secretion, and proliferation of prostate cancer Cells in vitro.
Journal ArticleDOI
The androgen receptor directly targets the cellular Fas/FasL-associated death domain protein-like inhibitory protein gene to promote the androgen-independent growth of prostate cancer cells.
Shen Gao,Peng Lee,Hua Wang,William L. Gerald,Michael Adler,Liying Zhang,Yun-Fang Wang,Zhengxin Wang +7 more
TL;DR: The results suggest that the androgen receptor affects survival and apoptosis of prostate cells through regulation of the c-FLIP gene in response to androgens, which is a potent inhibitor of Fas/FasL-mediated apoptosis.