L
Lora B. Sweeney
Researcher at Salk Institute for Biological Studies
Publications - 11
Citations - 3657
Lora B. Sweeney is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Semaphorin & Interneuron. The author has an hindex of 7, co-authored 10 publications receiving 3390 citations. Previous affiliations of Lora B. Sweeney include Stanford University & Howard Hughes Medical Institute.
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Journal ArticleDOI
Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase
Anne Brunet,Lora B. Sweeney,J. Fitzhugh Sturgill,Katrin F. Chua,Paul L. Greer,Yingxi Lin,Hien Tran,Sarah E. Ross,Raul Mostoslavsky,Haim Y. Cohen,Linda Hu,Hwei-Ling Cheng,Mark P. Jedrychowski,Steven P. Gygi,David A. Sinclair,Frederick W. Alt,Michael E. Greenberg +16 more
TL;DR: One way in which members of the Sir2 family of proteins may increase organismal longevity is by tipping FOXO-dependent responses away from apoptosis and toward stress resistance.
Journal ArticleDOI
Graded expression of semaphorin-1a cell-autonomously directs dendritic targeting of olfactory projection neurons.
TL;DR: Gradients of axon guidance molecules instruct the formation of continuous neural maps, such as the retinotopic map in the vertebrate visual system, but it is shown that molecular gradients can also instruct theformation of a discrete neural map.
Journal ArticleDOI
Temporal target restriction of olfactory receptor neurons by Semaphorin-1a/PlexinA-mediated axon-axon interactions.
Lora B. Sweeney,Africa Couto,Ya-Hui Chou,Daniela Berdnik,Barry J. Dickson,Liqun Luo,Takaki Komiyama +6 more
TL;DR: It is proposed that Sema-1a/PlexinA-mediated repulsion provides a mechanism by which early-arrived ORN axons constrain the target choices of late-arriving axons.
Journal ArticleDOI
A Combinatorial Semaphorin Code Instructs the Initial Steps of Sensory Circuit Assembly in the Drosophila CNS
Zhuhao Wu,Lora B. Sweeney,Joseph C. Ayoob,Kayam Chak,Benjamin J. Andreone,Tomoko Ohyama,Rex Kerr,Liqun Luo,Marta Zlatic,Alex L. Kolodkin +9 more
TL;DR: It is shown here that establishment of select CNS longitudinal tracts and formation of precise mechanosensory afferent innervation to the same CNS region are coordinately regulated by the secreted semaphorins Sema-2a and SemA-2b.
Journal ArticleDOI
Origin and Segmental Diversity of Spinal Inhibitory Interneurons.
Lora B. Sweeney,Jay B. Bikoff,Mariano I. Gabitto,Susan Brenner-Morton,Myungin Baek,Jerry H. Yang,Esteban G. Tabak,Jeremy S. Dasen,Chris Kintner,Thomas M. Jessell +9 more
TL;DR: It is shown that select combinations of nineteen transcription factors that specify lumbar V1 inhibitory interneurons generate subpopulations enriched at limb and thoracic levels, revealing a developmental program of V1 interneuron diversity.