L
Lora V. Hooper
Researcher at University of Texas Southwestern Medical Center
Publications - 134
Citations - 38472
Lora V. Hooper is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Immune system & Innate immune system. The author has an hindex of 65, co-authored 127 publications receiving 32542 citations. Previous affiliations of Lora V. Hooper include University of Washington & Howard Hughes Medical Institute.
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Journal ArticleDOI
The gut microbiota as an environmental factor that regulates fat storage
Fredrik Bäckhed,Hao Ding,Hao Ding,Ting Wang,Lora V. Hooper,Gou Young Koh,Andras Nagy,Clay F. Semenkovich,Jeffrey I. Gordon +8 more
TL;DR: In this article, the authors found that conventionalization of adult germ-free C57BL/6 mice with a normal microbiota harvested from the distal intestine (cecum) of conventionally raised animals produces a 60% increase in body fat content and insulin resistance within 14 days despite reduced food intake.
Journal ArticleDOI
Interactions between the microbiota and the immune system.
TL;DR: Advances in understanding of the interactions between resident microbes and the immune system are reviewed and the implications for human health are reviewed.
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Commensal Host-Bacterial Relationships in the Gut
Lora V. Hooper,Jeffrey I. Gordon +1 more
TL;DR: The current genomic revolution offers an unprecedented opportunity to identify the molecular foundations of symbionts and commensals so that the authors can understand how they contribute to their normal physiology and how they can be exploited to develop new therapeutic strategies.
Journal ArticleDOI
Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
TL;DR: Coloring germ-free mice with Bacteroides thetaiotaomicron reveals that this commensal bacterium modulates expression of genes involved in several important intestinal functions, including nutrient absorption, mucosal barrier fortification, xenobiotic metabolism, angiogenesis, and postnatal intestinal maturation.
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How host-microbial interactions shape the nutrient environment of the mammalian intestine
TL;DR: This paper showed that Bacteroides thetaiotaomicron, a prominent and genetically manipulatable component of the normal human and mouse gut, modifies many aspects of intestinal cellular differentiation/gene expression to benefit both host and microbe.