Lorena Lim

TL;DR: The experiments show that the HFH-11 transcription factor is expressed in embryonic mesenchymal and epithelial cells and its expression is reactivated in these adult cell types by proliferative signals or oxidative stress.

TL;DR: The phenotypes of transgenic and knockout mouse models are summarized, which define important functions of transcription factors in cellular differentiation and lung branching morphogenesis and the maintenance of differentiated gene expression.

TL;DR: In situ hybridization studies of staged specific embryos demonstrate that H NF-6 and its potential target gene, HNF-3 beta, are coexpressed in the pancreatic and hepatic diverticulum and interspecific backcross analysis determines that murine Hnf6 gene is located in the middle of mouse chromosome 9.

TL;DR: Reduction in the level of Foxf1 caused neonatal pulmonary hemorrhage and abnormalities in alveologenesis, implicating this transcription factor in the regulation of mesenchyme-epithelial interaction critical for lung morphogenesis.

TL;DR: It is shown that HFH-8 expression initiates during the primitive streak stage of mouse embryogenesis in the extraembryonic mesoderm and in the lateral Mesoderm which gives rise to the somatopleuric and splanchnopleuri mesoderman, suggesting a role in mesenchymal-epithelial induction of lung and gut morphogenesis.