L
Lorenzo Trippa
Researcher at Harvard University
Publications - 178
Citations - 4437
Lorenzo Trippa is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & Clinical trial. The author has an hindex of 28, co-authored 152 publications receiving 2782 citations. Previous affiliations of Lorenzo Trippa include Dana Corporation & Bocconi University.
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Journal ArticleDOI
Pathologic Complete Response after Neoadjuvant Chemotherapy and Impact on Breast Cancer Recurrence and Survival: A Comprehensive Meta-analysis.
Laura Spring,Geoffrey Fell,Andrea Arfè,Chandni Sharma,Rachel A. Greenup,Kerry L. Reynolds,Barbara L. Smith,Brian M. Alexander,Beverly Moy,Steven J. Isakoff,Giovanni Parmigiani,Lorenzo Trippa,Aditya Bardia +12 more
TL;DR: The similar outcomes with or without adjuvant chemotherapy in patients who attain pCR likely reflects tumor biology and systemic clearance of micrometastatic disease, highlighting the potential of escalation/deescalation strategies in the adjUvant setting based on neoadjuvant response.
Journal ArticleDOI
Bifurcation analysis of single-cell gene expression data reveals epigenetic landscape
Eugenio Marco,Robert L. Karp,Guoji Guo,Paul Robson,Adam H. Hart,Lorenzo Trippa,Guo-Cheng Yuan +6 more
TL;DR: SCUBA provides a useful single-cell data analysis tool that is well-suited for the investigation of developmental processes and analysis of a hematopoietic dataset suggests that the method is effective for reconstructing gene expression dynamics during human B-cell development.
Journal ArticleDOI
Prognostic role of circulating exosomal miRNAs in multiple myeloma
Salomon Manier,Salomon Manier,Chia Jen Liu,Chia Jen Liu,Chia Jen Liu,Hervé Avet-Loiseau,Jihye Park,Jiantao Shi,Federico Campigotto,Karma Salem,Daisy Huynh,Siobhan Glavey,Bradley Rivotto,Antonio Sacco,Antonio Sacco,Aldo M. Roccaro,Aldo M. Roccaro,Juliette Bouyssou,Stephane Minvielle,Philippe Moreau,Thierry Facon,Xavier Leleu,Edie Weller,Lorenzo Trippa,Irene M. Ghobrial +24 more
TL;DR: The findings support the use of circulating exosomal miRNAs to improve the identification of patients with newly diagnosed MM with poor outcomes, and require further validation in other independent prospective MM cohorts.
Journal ArticleDOI
Adaptive platform trials: definition, design, conduct and reporting considerations.
Derek C. Angus,Brian M. Alexander,Scott M. Berry,Meredith Buxton,Roger J. Lewis,Melissa Paoloni,Steven A R Webb,Steven E. Arnold,Anna D. Barker,Donald A. Berry,Marc J. M. Bonten,Mary Brophy,Christopher C Butler,Timothy F. Cloughesy,Lennie P. G. Derde,Laura J. Esserman,Ryan Ferguson,Louis D. Fiore,Sarah C. Gaffey,J. Michael Gaziano,Kathy Giusti,Herman Goossens,Stephane Heritier,Bradley T. Hyman,Michael Krams,Kay Larholt,Lisa M. LaVange,Philip W. Lavori,Andrew W. Lo,Alex John London,Victoria Manax,Colin McArthur,Genevieve K. O'Neill,Giovanni Parmigiani,Jane Perlmutter,Elizabeth Petzold,Craig W. Ritchie,Kathryn M Rowan,Christopher W. Seymour,Shapiro, Nathan, I,Diane M. Simeone,Bradley R. Smith,Bradley Spellberg,Ariel Dora Stern,Lorenzo Trippa,Mark R. Trusheim,Kert Viele,Patrick Y. Wen,Janet Woodcock +48 more
TL;DR: Common features and issues that arise with adaptive platform trials, which can study multiple therapeutic interventions in a disease in a perpetual manner, are reviewed and recommendations to improve the efficiency of drug development are put forward.
Journal ArticleDOI
On the restricted mean survival time curve in survival analysis.
Lihui Zhao,Brian Claggett,Lu Tian,Hajime Uno,Marc A. Pfeffer,Scott D. Solomon,Lorenzo Trippa,L. J. Wei +7 more
TL;DR: Inference, for instance, based on simultaneous confidence bands for a single RMST curve and also the difference between two RMST curves are proposed, which is informative for evaluating two groups under an equivalence or noninferiority setting, and quantifies the difference of two groups in a time scale.