Lori Fitz

TL;DR: It is reported here that the ligand of PD-1 (PD-L1), an immunoinhibitory receptor expressed by activated T cells, B cells, and myeloid cells, is a member of the B7 gene family.

TL;DR: Data strongly suggest that the same molecule mediates these three activities, although the presence of traces of contaminant peptides even in the most purified NKSF preparations does not allow us to exclude the possibility that distinct biologically active molecules have been co-purified.

TL;DR: The synergistic stimulation by NKSF plus IL-2 of T and NK function supports the possibility that these cytokines might prove useful in cancer therapy.

TL;DR: Examination of the functional consequences of PD‐1:PD‐L engagement on murine CD4 and CD8 T cells shows that these interactions result in inhibition of proliferation and cytokine production, and suggests that CD8+ T cells may be more sensitive to modulation by the PD‐ 1: PD‐L pathway because of their intrinsic inability to produce significant levels of IL‐2.

TL;DR: It is demonstrated that PD‐1 modulation of T‐cell function involves inhibition of TCR‐mediated phosphorylation of ZAP70 and association with CD3ζ andPD‐1 signaling attenuates PKCθ activation loop phosphorylated in a cognate TCR signal.