L
Lothar Gremer
Researcher at University of Düsseldorf
Publications - 81
Citations - 4662
Lothar Gremer is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: Fibril & Chemistry. The author has an hindex of 29, co-authored 71 publications receiving 3870 citations. Previous affiliations of Lothar Gremer include Forschungszentrum Jülich & Max Planck Society.
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Journal ArticleDOI
Fibril structure of amyloid-β(1-42) by cryo-electron microscopy.
Lothar Gremer,Lothar Gremer,Daniel Schölzel,Daniel Schölzel,Carla Schenk,Elke Reinartz,Jörg Labahn,Jörg Labahn,Raimond B. G. Ravelli,Markus Tusche,Carmen López-Iglesias,Wolfgang Hoyer,Wolfgang Hoyer,Henrike Heise,Henrike Heise,Dieter Willbold,Dieter Willbold,Gunnar F. Schröder,Gunnar F. Schröder +18 more
TL;DR: The complete structure of an Aβ(1–42) fibril composed of two intertwined protofilaments determined by cryo–electron microscopy (cryo-EM) and provides a structural basis for understanding the effect of several disease-causing and disease-preventing mutations.
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Crystal Structure of a Carbon Monoxide Dehydrogenase Reveals a [Ni-4Fe-5S] Cluster
TL;DR: This structure represents the prototype for Ni-containing CO dehydrogenases from anaerobic bacteria and archaea and contains five metal clusters of which clusters B, B′, and a subunit-bridging, surface-exposed cluster D are cubane-type [4Fe-4S] clusters.
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Catalysis at a dinuclear [CuSMo(=O)OH] cluster in a CO dehydrogenase resolved at 1.1-A resolution
TL;DR: The dinuclear [CuSMo(O)OH] cluster of CO dehydrogenase establishes a previously uncharacterized class of dinuclear molybdoenzymes containing the pterin cofactor.
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A restricted spectrum of NRAS mutations causes Noonan syndrome
Ion C. Cirstea,Kerstin Kutsche,Radovan Dvorsky,Lothar Gremer,Claudio Carta,Denise Horn,Amy E. Roberts,Amy E. Roberts,Francesca Romana Lepri,Torsten Merbitz-Zahradnik,Rainer König,Christian P. Kratz,Francesca Pantaleoni,Maria Lisa Dentici,Victoria A. Joshi,Victoria A. Joshi,Raju Kucherlapati,Laura Mazzanti,Stefan Mundlos,Michael A. Patton,Margherita Silengo,Cesare Rossi,Giuseppe Zampino,Cristina Digilio,Liborio Stuppia,Eva Seemanova,Len A. Pennacchio,Len A. Pennacchio,Bruce D. Gelb,Bruno Dallapiccola,Alfred Wittinghofer,Mohammad Reza Ahmadian,Marco Tartaglia,Martin Zenker +33 more
TL;DR: Evidence is provided for an obligate dependency on proper NRAS function in human development and growth and for germline NRAS mutations conferring enhanced stimulus-dependent MAPK activation in some cases of Noonan syndrome.
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Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo
Shehab Ismail,Yong-Xiang Chen,Alexandra Rusinova,Anchal Chandra,Martin Bierbaum,Lothar Gremer,Gemma Triola,Herbert Waldmann,Philippe I. H. Bastiaens,Alfred Wittinghofer +9 more
TL;DR: The structure of fully modified farnesylated Rheb-GDP in complex with PDEδ is reported and it is demonstrated that the G proteins Arl2 and Arl3 act in a GTP-dependent manner as allosteric release factors for farnesyated cargo.