L
Louis Boon
Researcher at University of Amsterdam
Publications - 383
Citations - 20067
Louis Boon is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 70, co-authored 358 publications receiving 16801 citations. Previous affiliations of Louis Boon include Janssen Pharmaceutica & Katholieke Universiteit Leuven.
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Journal ArticleDOI
Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis
Leslie van der Fits,Sabine Mourits,Jane S. A. Voerman,Marius Kant,Louis Boon,Jon D. Laman,Ferry Cornelissen,Anne-Marie Mus,Edwin Florencia,Errol P. Prens,Erik Lubberts +10 more
TL;DR: The sole application of the innate TLR7/8 ligand IMQ rapidly induces a dermatitis closely resembling human psoriasis, critically dependent on the IL-23/IL-17 axis.
Journal ArticleDOI
Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells
Maria Teresa Pallotta,Ciriana Orabona,Claudia Volpi,Carmine Vacca,Maria Laura Belladonna,Roberta Bianchi,Giuseppe Servillo,Cinzia Brunacci,Mario Calvitti,Silvio Bicciato,Emilia Maria Cristina Mazza,Louis Boon,Fabio Grassi,Maria C. Fioretti,Francesca Fallarino,Paolo Puccetti,Ursula Grohmann +16 more
TL;DR: It is found that IDO was involved in intracellular signaling events responsible for the self-amplification and maintenance of a stably regulatory phenotype in pDCs and has a tonic, nonenzymic function that contributes to TGF-β-driven tolerance in noninflammatory contexts.
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Aryl hydrocarbon receptor control of a disease tolerance defence pathway
Alban Bessede,Alban Bessede,Marco Gargaro,Maria Teresa Pallotta,Davide Matino,Giuseppe Servillo,Cinzia Brunacci,Silvio Bicciato,Emilia Maria Cristina Mazza,Antonio Macchiarulo,Carmine Vacca,Rossana G. Iannitti,Luciana Tissi,Claudia Volpi,Maria Laura Belladonna,Ciriana Orabona,Roberta Bianchi,Tobias V. Lanz,Michael Platten,Maria Agnese Della Fazia,Danilo Piobbico,Teresa Zelante,Hiroshi Funakoshi,Toshikazu Nakamura,David Gilot,Michael S. Denison,Gilles J. Guillemin,James B. DuHadaway,George C. Prendergast,Richard P. Metz,Michel Geffard,Louis Boon,Matteo Pirro,Alfonso Iorio,Bernard Veyret,Luigina Romani,Ursula Grohmann,Francesca Fallarino,Paolo Puccetti +38 more
TL;DR: It was found that a first exposure of mice to LPS activated the ligand-operated transcription factor aryl hydrocarbon receptor and the hepatic enzyme tryptophan 2,3-dioxygenase, which provided an activating ligand to the former, to downregulate early inflammatory gene expression, pointing to a role for AhR in contributing to host fitness.
Journal ArticleDOI
Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy.
Ursula Grohmann,Claudia Volpi,Francesca Fallarino,Silvia Bozza,Roberta Bianchi,Carmine Vacca,Ciriana Orabona,Maria Laura Belladonna,Emira Ayroldi,Giuseppe Nocentini,Louis Boon,Francesco Bistoni,Maria C. Fioretti,Luigina Romani,Carlo Riccardi,Paolo Puccetti +15 more
TL;DR: It is shown that reverse signaling through GITRL after engagement by soluble GITR initiates the immunoregulatory pathway of tryptophan catabolism in mouse plasmacytoid dendritic cells, by means of noncanonical NF-κB–dependent induction of indoleamine 2,3-dioxygenase (IDO).
Journal ArticleDOI
Transfer of Central Nervous System Autoantigens and Presentation in Secondary Lymphoid Organs
Alex F. de Vos,Marjan van Meurs,Herbert P.M. Brok,Leonie A. Boven,Rogier Q. Hintzen,Paul van der Valk,Rivka Ravid,Susanne Rensing,Louis Boon,Bert A. 't Hart,Jon D. Laman +10 more
TL;DR: The findings suggest that during MS and EAE, modulation of T cell reactivity against brain-derived Ags also takes place in cervical LN and not necessarily inside the brain, thereby circumventing the blood-brain barrier.