Author
Louis Fieser
Other affiliations: Merck & Co., University of Basel
Bio: Louis Fieser is an academic researcher from Harvard University. The author has contributed to research in topics: Coupling reaction & Allylic rearrangement. The author has an hindex of 47, co-authored 874 publications receiving 8359 citations. Previous affiliations of Louis Fieser include Merck & Co. & University of Basel.
Papers published on a yearly basis
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Book•
01 Jan 1935
TL;DR: The first steps in safety practices in the organic chemistry laboratory are outlined in this paper and guidelines for notebooks are discussed. But safety practices are not discussed in detail in this paper.
Abstract: simple experiments Organic Chemistry Science Forums EXPERIMENTS IN ORGANIC CHEMISTRY From Microscale to Macroseale Jonathan S. Nimitz University of New Mexico WM PRENTICE HALL, Englewood Cliffs, New Jersey 07632 . PREFACE xiii LABORATORY The First Steps 1 ESSENTIALS Safety Practices in the Organic Laboratory 4 First Aid 7 Guidelines for Notebooks 8 Note on Calculating Theoretical Yields 10 Typical Organic Chemistry Desk Equipment 12 General ...
354 citations
211 citations
199 citations
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University of British Columbia1, University of North Carolina at Chapel Hill2, National Academy of Sciences of Ukraine3, University of Strasbourg4, Moscow State University5, Liverpool John Moores University6, University of Insubria7, University of Milano-Bicocca8, Istituto Superiore di Sanità9, Ohio State University10, Research Triangle Park11
TL;DR: In this paper, the authors provide guidelines for QSAR development, validation, and application, which are summarized in best practices for building rigorously validated and externally predictive quantitative structure-activity relationship models.
Abstract: Quantitative structure–activity relationship modeling is one of the major computational tools employed in medicinal chemistry. However, throughout its entire history it has drawn both praise and criticism concerning its reliability, limitations, successes, and failures. In this paper, we discuss (i) the development and evolution of QSAR; (ii) the current trends, unsolved problems, and pressing challenges; and (iii) several novel and emerging applications of QSAR modeling. Throughout this discussion, we provide guidelines for QSAR development, validation, and application, which are summarized in best practices for building rigorously validated and externally predictive QSAR models. We hope that this Perspective will help communications between computational and experimental chemists toward collaborative development and use of QSAR models. We also believe that the guidelines presented here will help journal editors and reviewers apply more stringent scientific standards to manuscripts reporting new QSAR stu...
1,314 citations
TL;DR: The most important aspects referring to irreversible adsorption of phenols and impact of different substituents of phenolic compounds on their uptake by activated carbons is considered.
1,249 citations
TL;DR: One of the goals of this Review is to attract the attention of the scientific community as to the benefits of using hypervalent iodine compounds as an environmentally sustainable alternative to heavy metals.
Abstract: The preparation, structure, and chemistry of hypervalent iodine compounds are reviewed with emphasis on their synthetic application. Compounds of iodine possess reactivity similar to that of transition metals, but have the advantage of environmental sustainability and efficient utilization of natural resources. These compounds are widely used in organic synthesis as selective oxidants and environmentally friendly reagents. Synthetic uses of hypervalent iodine reagents in halogenation reactions, various oxidations, rearrangements, aminations, C–C bond-forming reactions, and transition metal-catalyzed reactions are summarized and discussed. Recent discovery of hypervalent catalytic systems and recyclable reagents, and the development of new enantioselective reactions using chiral hypervalent iodine compounds represent a particularly important achievement in the field of hypervalent iodine chemistry. One of the goals of this Review is to attract the attention of the scientific community as to the benefits of...
1,228 citations
1,062 citations
TL;DR: The synthesis of 4-dialkylaminopyridines can be accomplished in two steps starting from pyridine as discussed by the authors, and these derivatives are approximately 104 times more active when used as acylation catalysts.
Abstract: The synthesis of 4-dialkylaminopyridines can be accomplished in two steps starting from pyridine. Compared to pyridine, these derivatives are approximately 104 times more active when used as acylation catalysts. Dialkylaminopyridines are being used with ever-increasing frequency for acylation reactions which proceed either incompletely or not at all in pyridine. This article reviews the various possible applications of 4-dialkylaminopyridines in terpene, steroid, carbohydrate and nucleoside chemistry as well as in the transformation of amino acids into α-acyl aminoketones and polymerization of isocyanates. In addition, N-substituted 4-dialkylaminopyridinium salts can be used for the transfer of sensitive groups to nucleophiles in aqueous medium. The exceptional catalytic effect of these derivatives, even in non-polar solvents, is due, in part, to the formation of high concentrations of N-acylpyridinium salts which are present in solution as loosely-bound, highly reactive ion pairs.
1,007 citations