L
Louise Brown
Researcher at University College London
Publications - 81
Citations - 6039
Louise Brown is an academic researcher from University College London. The author has contributed to research in topics: Prostate cancer & Medicine. The author has an hindex of 23, co-authored 67 publications receiving 4906 citations. Previous affiliations of Louise Brown include Medical Research Council.
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Journal ArticleDOI
Diagnostic accuracy of multi-parametric MRI and TRUS biopsy in prostate cancer (PROMIS): a paired validating confirmatory study
Hashim U. Ahmed,Hashim U. Ahmed,Ahmed El-Shater Bosaily,Ahmed El-Shater Bosaily,Louise Brown,Rhian Gabe,Richard Kaplan,Mahesh K.B. Parmar,Yolanda Collaco-Moraes,Katie Ward,Richard Hindley,Alex Freeman,Alex Kirkham,Robert Oldroyd,Chris Parker,Mark Emberton,Mark Emberton +16 more
TL;DR: Using MP-MRI to triage men might allow 27% of patients avoid a primary biopsy and diagnosis of 5% fewer clinically insignificant cancers, as well as reduce unnecessary biopsies by a quarter.
Mortality results for randomised controlled trial of early elective surgery or ultrasonographic surveillance for small abdominal aortic aneurysms. The UK Small Aneurysm Trial Participants
TL;DR: In this article, the authors investigated whether prophylactic open surgery decreased long-term mortality risks for small aneurysms and found that the risk of rupture seems to be low for small abdominal aortic anusms smaller than 5 cm.
Journal Article
Mortality results for randomised controlled trial of early elective surgery or ultrasonographic surveillance for small abdominal aortic aneurysms
Charles McCollum,Janet T. Powell,A. R. Brady,Louise Brown,John F. Forbes,F. G. R. Fowkes,Roger M. Greenhalgh,C. V. Ruckley,Simon G. Thompson +8 more
TL;DR: The results do not support a policy of open surgical repair for abdominal aortic aneurysms of 4.0-5.5 cm in diameter, and early surgery does not provide a long-term survival advantage.
Journal ArticleDOI
Systematic review and meta-analysis of the growth and rupture rates of small abdominal aortic aneurysms: implications for surveillance intervals and their cost-effectiveness
Simon G. Thompson,Louise Brown,Michael J. Sweeting,Matthew J. Bown,Lois G. Kim,Matthew Glover,Martin Buxton,Janet T. Powell +7 more
TL;DR: Surveillance intervals of several years are clinically acceptable for men with AAAs in the range 3.0-4.0 cm, and future work should focus on optimising surveillance intervals for women, studying whether or not the threshold for surgery should depend on patient characteristics, and evaluating the usefulness of surveillance for those with aortic diameters of 2.5-2.9 cm.
Journal ArticleDOI
The adjuvant benefit of angioplasty in patients with mild to moderate intermittent claudication (MIMIC) managed by supervised exercise, smoking cessation advice and best medical therapy: results from two randomised trials for stenotic femoropopliteal and aortoiliac arterial disease
Roger M. Greenhalgh,Jill J. F. Belch,Louise Brown,P A Gaines,L Gao,J. A. Reise,Simon G. Thompson,Mimic Trial Participants +7 more
TL;DR: PTA confers adjuvant benefit over supervised exercise and best medical therapy in terms of walking distances and ABPI 24 months after PTA in patients with stable mild to moderate intermittent claudication.