L
Louise Slater
Researcher at National Institutes of Health
Publications - 4
Citations - 1587
Louise Slater is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Rhinovirus & Exacerbation. The author has an hindex of 4, co-authored 4 publications receiving 1473 citations.
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Journal ArticleDOI
Role of deficient type III interferon-λ production in asthma exacerbations
Marco Contoli,Simon D. Message,Vasile Laza-Stanca,Michael R. Edwards,Peter A. B. Wark,Peter A. B. Wark,Nathan W. Bartlett,Tatiana Kebadze,Patrick Mallia,Luminita A. Stanciu,Hayley L. Parker,Louise Slater,Anita Lewis-Antes,Onn Min Kon,Stephen T. Holgate,Donna E. Davies,Sergei V. Kotenko,Alberto Papi,Sebastian L. Johnston +18 more
TL;DR: In this paper, the authors show deficient induction of interferon-λs by rhinovirus in primary bronchial epithelial cells and alveolar macrophages, which was highly correlated with severity of rhinovirus induced asthma exacerbation and virus load in experimentally infected human volunteers.
Journal ArticleDOI
Experimental Rhinovirus Infection as a Human Model of Chronic Obstructive Pulmonary Disease Exacerbation
Patrick Mallia,Simon D. Message,V Gielen,Marco Contoli,Katrina Gray,Tatiana Kebadze,Julia Aniscenko,Vasile Laza-Stanca,Michael R. Edwards,Louise Slater,Alberto Papi,Luminita A. Stanciu,Onn Min Kon,Malcolm Johnson,Sebastian L. Johnston +14 more
TL;DR: A new model of COPD exacerbation is developed that strongly supports a causal relationship between rhinovirus infection and COPD alleviation and impaired IFN production and neutrophilic inflammation may be important mechanisms in virus-induced COPd exacerbations.
Journal ArticleDOI
Co-ordinated Role of TLR3, RIG-I and MDA5 in the Innate Response to Rhinovirus in Bronchial Epithelium
Louise Slater,Nathan W. Bartlett,JJ Haas,Jie Zhu,Simon D. Message,Ross P. Walton,Annemarie Sykes,Samer Dahdaleh,Deborah L. Clarke,Maria G. Belvisi,Onn Min Kon,Takashi Fujita,Peter K. Jeffery,Sebastian L. Johnston,Michael R. Edwards +14 more
TL;DR: Anti-viral defense within bronchial epithelium requires co-ordinated recognition of rhinovirus infection, initially via TLR3/TRIF and later via inducible RNA helicases.
Journal ArticleDOI
Signalling pathways mediating type I interferon gene expression
TL;DR: This review provides a timely summary of this rapidly expanding field, focusing specifically on the various viral RNA binding molecules and their associated signalling pathways.