L
Lowell Umayam
Researcher at Howard Hughes Medical Institute
Publications - 28
Citations - 11140
Lowell Umayam is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Genome & Connectome. The author has an hindex of 21, co-authored 26 publications receiving 10164 citations. Previous affiliations of Lowell Umayam include J. Craig Venter Institute.
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Journal ArticleDOI
DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae
John F. Heidelberg,Jonathan A. Eisen,William C. Nelson,Rebecca A. Clayton,Michelle L. Gwinn,Robert J. Dodson,Daniel H. Haft,Erin Hickey,Jeremy Peterson,Lowell Umayam,Steven R. Gill,Karen E. Nelson,Timothy D. Read,Hervé Tettelin,Delwood Richardson,Maria D. Ermolaeva,Jessica Vamathevan,Steven Bass,Haiying Qin,Ioana Dragoi,Patrick Sellers,Lisa McDonald,Teresa Utterback,Robert D. Fleishmann,William C. Nierman,Owen White,Steven L. Salzberg,Hamilton O. Smith,Rita R. Colwell,Rita R. Colwell,John J. Mekalanos,J. Craig Venter,Claire M. Fraser +32 more
TL;DR: The V. cholerae genomic sequence provides a starting point for understanding how a free-living, environmental organism emerged to become a significant human bacterial pathogen.
Journal ArticleDOI
Complete Genome Sequence of a Virulent Isolate of Streptococcus pneumoniae
Hervé Tettelin,Karen E. Nelson,Ian T. Paulsen,Jonathan A. Eisen,Timothy D. Read,Scott N. Peterson,John F. Heidelberg,Robert T. DeBoy,Daniel H. Haft,Robert J. Dodson,Anthony S. Durkin,Michelle L. Gwinn,James F. Kolonay,William C. Nelson,Jeremy Peterson,Lowell Umayam,Owen White,Steven L. Salzberg,Matthew R. Lewis,Diana Radune,Erik Holtzapple,Hoda Khouri,Alex M. Wolf,T. Utterback,Cheryl L. Hansen,Lisa McDonald,Tamara Feldblyum,Samuel V. Angiuoli,T. Dickinson,Erin Hickey,Ingeborg Holt,Brendan J. Loftus,Fan Yang,Hamilton O. Smith,J. C. Venter,Brian Dougherty,Donald A. Morrison,S. K. Hollingshead,Claire M. Fraser +38 more
TL;DR: A motif identified within the signal peptide of proteins is potentially involved in targeting these proteins to the cell surface of low–guanine/cytosine Gram-positive species.
Journal ArticleDOI
Role of Mobile DNA in the Evolution of Vancomycin-Resistant Enterococcus faecalis
Ian T. Paulsen,L. Banerjei,Garry S. A. Myers,Karen E. Nelson,Rekha Seshadri,Timothy D. Read,Derrick E. Fouts,Jonathan A. Eisen,Steven R. Gill,John F. Heidelberg,H Tettelin,Robert J. Dodson,Lowell Umayam,Lauren M. Brinkac,Maureen J. Beanan,Sean C. Daugherty,Robert T. DeBoy,Scott Durkin,James F. Kolonay,R. Madupu,William C. Nelson,Jessica Vamathevan,Bao Tran,J. Upton,T. Hansen,Jyoti Shetty,H. Khouri,T. Utterback,Diana Radune,K. A. Ketchum,Brian Dougherty,Claire M. Fraser +31 more
TL;DR: The complete genome sequence of Enterococcus faecalisV583, a vancomycin-resistant clinical isolate, revealed that more than a quarter of the genome consists of probable mobile or foreign DNA, which probably contributed to the rapid acquisition and dissemination of drug resistance in the enterococci.
Journal ArticleDOI
Genome sequence of the dissimilatory metal ion-reducing bacterium Shewanella oneidensis.
John F. Heidelberg,Ian T. Paulsen,Karen E. Nelson,Eric Gaidos,Eric Gaidos,William C. Nelson,Timothy D. Read,Jonathan A. Eisen,Rekha Seshadri,Naomi L. Ward,Barbara A. Methé,Rebecca A. Clayton,Terry E. Meyer,A. I. Tsapin,James Scott,Maureen J. Beanan,Lauren M. Brinkac,Sean C. Daugherty,Robert T. DeBoy,Robert J. Dodson,A. Scott Durkin,Daniel H. Haft,James F. Kolonay,Ramana Madupu,Jeremy Peterson,Lowell Umayam,Owen White,Alex M. Wolf,Jessica Vamathevan,Janice Weidman,Marjorie Impraim,K. Lee,Kristy Berry,Chris Lee,Jacob L. Mueller,Hoda Khouri,John Gill,T. Utterback,Lisa McDonald,Tamara Feldblyum,Hamilton O. Smith,J. Craig Venter,Kenneth H. Nealson,Kenneth H. Nealson,Claire M. Fraser +44 more
TL;DR: This genome sequence represents a critical step in the elucidation of the pathways for reduction (and bioremediation) of pollutants such as uranium (U) and chromium (Cr), and offers a starting point for defining this organism's complex electron transport systems and metal ion–reducing capabilities.
Journal ArticleDOI
Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana
Xiaoying Lin,Samir Kaul,Steve Rounsley,Terrance Shea,Maria-Ines Benito,Christopher D. Town,Claire Fujii,Tanya Mason,Cheryl Bowman,Mary Barnstead,Tamara Feldblyum,C. Robin Buell,Karen A. Ketchum,John Lee,Catherine M. Ronning,Hean L. Koo,Kelly Moffat,Lisa A. Cronin,Mian Shen,Grace Pai,Susan Van Aken,Lowell Umayam,Luke J. Tallon,John Gill,Mark Raymond Adams,Ana J. Carrera,Todd Creasy,Howard M. Goodman,Chris Somerville,Gregory P. Copenhaver,Daphne Preuss,William C. Nierman,Owen White,Jonathan A. Eisen,Steven L. Salzberg,Claire M. Fraser,J. Craig Venter +36 more
TL;DR: The sequence of chromosome 2 from the Columbia ecotype is reported in two gap-free assemblies (contigs) of 3.6 and 16 megabases, which represents the longest published stretch of uninterrupted DNA sequence assembled from any organism to date.