Lu Jin

TL;DR: A novel role for GRP78 is revealed in the integration of cellular signaling pathways including the unfolded protein response, apoptosis, and autophagy to determine cell fate in response to antiestrogen therapy.

TL;DR: This work shows a direct link between the XBP1 and NF-κB survival pathways in driving the cell fate decisions in response to antiestrogens in ER+ breast cancer cells, both in vitro and in a xenograft mouse model.

TL;DR: It is discovered that culture on collagen-I gels (VitrogenTM; Vg) induces MMP-2-activator in highly invasive but not poorly invasive HBC cell lines, and cooperativity may exist in vivo for MMP -2 participation in HBC dissemination.

TL;DR: This work has developed a Cytoscape plug-in, CytoDDN, to integrate network analysis and visualization seamlessly and serves as a useful systems biology tool for users across biomedical research communities to infer how genetic, epigenetic or environment variables may affect biological networks and clinical phenotypes.

TL;DR: Paternal consumption of animal- or plant-based high-fat diets elicited opposing effects, with lard rich in saturated fatty acids increasing breast cancer risk in offspring and corn oil rich in n-6 polyunsaturated fatty acids decreasing it.