L
Lu-yao Ao
Researcher at China Pharmaceutical University
Publications - 14
Citations - 280
Lu-yao Ao is an academic researcher from China Pharmaceutical University. The author has contributed to research in topics: In vivo & Neuropathic pain. The author has an hindex of 7, co-authored 12 publications receiving 170 citations.
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Journal ArticleDOI
Research progress of mechanisms and drug therapy for neuropathic pain
TL;DR: The anatomical physiology, underlying mechanisms of neuropathic pain is overviewed to provide a better understanding in the initiation, development, maintenance, and modulation of this pervasive disease, and inspire research in the unclear mechanisms as well as potential targets.
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Levo-corydalmine alleviates vincristine-induced neuropathic pain in mice by inhibiting an NF-kappa B-dependent CXCL1/CXCR2 signaling pathway
Lin Zhou,Yahui Hu,Cheng-yuan Li,Yun-yi Yan,Lu-yao Ao,Boyang Yu,Weirong Fang,Ji-Hua Liu,Yunman Li +8 more
TL;DR: The data demonstrate that an NF&kgr;B‐dependent CXCL1/CXCR2 signaling pathway is involved in vincristine‐induced neuropathic pain and suggest that l‐CDL likely attenuates this inflammation through down‐regulation of this signaling pathway.
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Immune Cells After Ischemic Stroke Onset: Roles, Migration, and Target Intervention
TL;DR: This review summarizes the multistep process of periphery immune cell extravasation into brain parenchyma during immunosurveillance and chronic inflammation after ischemic stroke onset and highlights promising target intervention, which may promote the development of future therapeutics for isChemic stroke.
Journal ArticleDOI
Levo-corydalmine Attenuates Vincristine-Induced Neuropathic Pain in Mice by Upregulating the Nrf2/HO-1/CO Pathway to Inhibit Connexin 43 Expression.
Lin Zhou,Lu-yao Ao,Yun-yi Yan,Cheng-yuan Li,Wanting Li,Anqi Ye,Ji-Hua Liu,Yahui Hu,Weirong Fang,Yunman Li +9 more
TL;DR: It is suggested that l-CDL likely protects against nerve damage and attenuates vincristine-induced neuroinflammation by upregulating Nrf2/HO-1/CO to inhibit Cx43 expression.
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Targeting pyroptosis to regulate ischemic stroke injury: Molecular mechanisms and preclinical evidences
TL;DR: The feasibility of therapeutic strategies targeting pyroptosis in the context of ischemic stroke is hypothesized based on the review of molecular mechanisms and evidences for pyroPTosis involvement in different kinds of the central nervous system cells.