Luc Aguilar

TL;DR: In situ hybridization demonstrated that endothelial cells constitute a major source of IL-33 mRNA in chronically inflamed tissues from patients with rheumatoid arthritis and Crohn's disease, and data suggest thatIL-33 is a dual function protein that may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties.

TL;DR: It is shown that THAP1 is a physiologic regulator of EC proliferation and cell-cycle progression, 2 essential processes for angiogenesis and the first links in mammals among THAP proteins, cell proliferation, and pRB/E2F cell- cycle pathways.

TL;DR: Compared the specificity of seven endothelial cell markers in the rheumatoid synovium and the colon of patients with Crohn's disease and found MECA‐79, which recognizes sulphated ligands for leukocyte adhesion receptor L‐selectin (CD62L), was selective for a subset of venules in highly inflamed tissue.

TL;DR: Better knowledge of molecular and functional changes occurring in endothelial cells during chronic inflammation may lead to the development of endothelium-targeted therapies for rheumatoid arthritis and other chronic inflammatory diseases.

TL;DR: The results show the selective induction of a CXCL8 binding site on endothelial syndecan-3 in RA synovium, which may be involved in leukocyte trafficking into RAsynovial tissue.