Luc Bousset

TL;DR: It is demonstrated that distinct α-SYN strains display differential seeding capacities, inducing strain-specific pathology and neurotoxic phenotypes, and α- SYN assemblies cross the blood–brain barrier and distribute to the central nervous system after intravenous injection.

TL;DR: It is shown that the two strains of α-synuclein have different structures, levels of toxicity, and in vitro and in vivo seeding and propagation properties, which may account for differences in disease progression in different individuals/cell types and/or types of synucleinopathies.

TL;DR: The first experimental evidence that different α-synuclein forms can propagate from the gut to the brain is provided, and that microtubule-associated transport is involved in the translocation of aggregated α- synuclein in neurons is provided.

TL;DR: A French family with a parkinsonian–pyramidal syndrome harboring a novel heterozygous SNCA mutation is described.

TL;DR: The axonal transport of α‐synuclein fibrils is characterized and quantified and it is shown thatfibrils could be transferred from axons to second‐order neurons following anterograde transport.